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SCN5A sodium voltage-gated channel alpha subunit 5 [ Gallus gallus (chicken) ]

Gene ID: 395947, updated on 10-Oct-2024

Summary

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Symbol
SCN5Aprovided by CGNC
Full Name
sodium voltage-gated channel alpha subunit 5provided by CGNC
Primary source
CGNC:49568
See related
Ensembl:ENSGALG00010027095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

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See SCN5A in Genome Data Viewer
Location:
chromosome: 2
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (5433099..5638472)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (5436015..5641603)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 11 Neighboring gene voltage-gated sodium channel SNS Neighboring gene activin A receptor type 2B Neighboring gene exo/endonuclease G Neighboring gene microRNA 6600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons. Friedel RH, et al. Proc Natl Acad Sci U S A, 1997 Nov 11. PMID 9356508, Free PMC Article
  2. Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity. Zakon HH, et al. Mol Biol Evol, 2011 Apr. PMID 21148285, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 5 subunit alpha
Names
oltage-gated sodium channel type V alpha
sodium channel, voltage-gated, type V, alpha subunit
voltage-dependent sodium channel SCN10A
voltage-gated sodium channel H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318446.3 → NP_001305375.3  sodium channel protein type 5 subunit alpha

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000035
    Related
    ENSGALP00010039935.1, ENSGALT00010065669.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5433099..5638472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040675933.2 → XP_040531867.1  sodium channel protein type 5 subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8V1A735
    Related
    ENSGALP00010039940.1, ENSGALT00010065674.1
    Conserved Domains (2) summary
    PLN03223
    Location:1624 → 1803
    PLN03223; Polycystin cation channel protein; Provisional
    cd13433
    Location:1487 → 1539
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

  2. XM_040675923.2 → XP_040531857.1  sodium channel protein type 5 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V1A735
    Conserved Domains (2) summary
    PLN03223
    Location:1624 → 1803
    PLN03223; Polycystin cation channel protein; Provisional
    cd13433
    Location:1487 → 1539
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

  3. XM_015281250.4 → XP_015136736.3  sodium channel protein type 5 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8V1A735
    Conserved Domains (2) summary
    PLN03223
    Location:1623 → 1802
    PLN03223; Polycystin cation channel protein; Provisional
    cd13433
    Location:1486 → 1538
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

  4. XM_015281251.4 → XP_015136737.3  sodium channel protein type 5 subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A8V1A9N2
    Related
    ENSGALP00010039942.1, ENSGALT00010065676.1
    Conserved Domains (2) summary
    PLN03223
    Location:1575 → 1754
    PLN03223; Polycystin cation channel protein; Provisional
    cd13433
    Location:1438 → 1490
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

  5. XM_015281252.4 → XP_015136738.3  sodium channel protein type 5 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V1A735
    Conserved Domains (2) summary
    PLN03223
    Location:1490 → 1669
    PLN03223; Polycystin cation channel protein; Provisional
    cd13433
    Location:1353 → 1405
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5436015..5641603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910387.1 → XP_046766343.1  sodium channel protein type 5 subunit alpha isoform X2

  2. XM_046910386.1 → XP_046766342.1  sodium channel protein type 5 subunit alpha isoform X1

  3. XM_046910388.1 → XP_046766344.1  sodium channel protein type 5 subunit alpha isoform X3

  4. XM_046910389.1 → XP_046766345.1  sodium channel protein type 5 subunit alpha isoform X4

  5. XM_046910390.1 → XP_046766346.1  sodium channel protein type 5 subunit alpha isoform X5

Nucleotide Protein
Heading Accession and Version

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