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TSHB thyroid stimulating hormone beta [ Gallus gallus (chicken) ]

Gene ID: 395937, updated on 10-Oct-2024

Summary

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Symbol
TSHBprovided by CGNC
Full Name
thyroid stimulating hormone betaprovided by CGNC
Primary source
CGNC:1832
See related
Ensembl:ENSGALG00010025394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TSH-B
Orthologs
human mouse all
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Genomic context

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See TSHB in Genome Data Viewer
Location:
chromosome: 26
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (4016750..4023301)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (3984541..3991082)

Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene suppressor of IKBKE 1 Neighboring gene bile acid receptor-like Neighboring gene synaptonemal complex protein 1 Neighboring gene tetraspanin 2 Neighboring gene nerve growth factor Neighboring gene uncharacterized LOC101747934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone β expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus. Dunn IC, et al. J Neuroendocrinol, 2017 Dec. PMID 29117457, Free PMC Article
  2. Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland. Nakamura K, et al. Cells Tissues Organs, 2004. PMID 15237192
  3. Complementary DNA sequence of chicken thyroid-stimulating hormone (TSH) beta subunit. Kato Y, et al. Endocr J, 1998 Aug. PMID 9881912
  4. Cloning and sequence analysis of a cDNA for the beta subunit of chicken thyroid-stimulating hormone. Gregory CC, et al. Gen Comp Endocrinol, 1997 Aug. PMID 9245526
  5. Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary. Huang G, et al. Endocrinology, 2014 Nov. PMID 25076122

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thyrotrophin-stimulating hormone beta expression changes in a dynamic fashion both diurnally and in response to photoperiod.
    Title: Diurnal and photoperiodic changes in thyrotrophin-stimulating hormone β expression and associated regulation of deiodinase enzymes (DIO2, DIO3) in the female juvenile chicken hypothalamus.
  2. Hypothalamic GCGL is most likely to be a novel TSH-releasing factor functioning in chickens, controlling the temporal expression of TSHb in the pituitary.
    Title: Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary.
  3. the expression of chicken TSHbeta mRNA starts on E9, TSHbeta-ip cells appear on E10, mainly in the cephalic lobe, and TSHbeta-ip cells can be classified into two cell types
    Title: Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyrotropin subunit beta
Names
TSH-beta
thyroid-stimulating hormone beta subunit
thyroid-stimulating hormone subunit beta
thyroptin beta subunit
thyrotropin beta chain
thyrotropin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205063.4 → NP_990394.1  thyrotropin subunit beta precursor

    See identical proteins and their annotated locations for NP_990394.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000356
    UniProtKB/Swiss-Prot
    O57340
    UniProtKB/TrEMBL
    A5YW28, Q7T051
    Related
    ENSGALP00010038296.1, ENSGALT00010062007.1
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4016750..4023301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025143670.3 → XP_024999438.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    O57340
    UniProtKB/TrEMBL
    A5YW28, Q7T051
    Conserved Domains (1) summary
    smart00068
    Location:20 → 126
    GHB; Glycoprotein hormone beta chain homologues

  2. XM_046904102.1 → XP_046760058.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    O57340
    UniProtKB/TrEMBL
    A5YW28

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3984541..3991082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046932884.1 → XP_046788840.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    O57340
    UniProtKB/TrEMBL
    A5YW28

  2. XM_046932883.1 → XP_046788839.1  thyrotropin subunit beta isoform X1

    UniProtKB/Swiss-Prot
    O57340
    UniProtKB/TrEMBL
    A5YW28
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O57340.1 GenPept UniProtKB/Swiss-Prot:O57340

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.