PTPN11 protein tyrosine phosphatase non-receptor type 11 [Gallus gallus (chicken)] - Gene

Summary

Symbol: PTPN11provided by CGNC
Full Name: protein tyrosine phosphatase non-receptor type 11provided by CGNC
Primary source: CGNC:49495
See related: Ensembl:ENSGALG00010020701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SYP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (6401646..6426410)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (6412221..6436966)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that SHP2-mediated tyrosine dephosphorylation is an important step in Sema4D-induced axon repulsion.
Title: Protein tyrosine phosphatase SHP2 is involved in Semaphorin 4D-induced axon repulsion.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 11

Names: SH-PTP2; cSH-PTP2

NP_990299.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204968.2 → NP_990299.1 tyrosine-protein phosphatase non-receptor type 11

See identical proteins and their annotated locations for NP_990299.1

Status: VALIDATED

Source sequence(s)

JAENSK010000260

UniProtKB/Swiss-Prot

Q90687

UniProtKB/TrEMBL

A0A8V0ZFN3

Related

ENSGALP00010029554.1, ENSGALT00010050025.1

Conserved Domains (3) summary

cd09931
Location:111 → 218

SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd10340
Location:5 → 103

SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins

cd14605
Location:272 → 524

PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11