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HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 [ Gallus gallus (chicken) ]

Gene ID: 395785, updated on 10-Oct-2024

Summary

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Symbol
HSD17B4provided by CGNC
Full Name
hydroxysteroid 17-beta dehydrogenase 4provided by CGNC
Primary source
CGNC:1559
See related
Ensembl:ENSGALG00010009280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See HSD17B4 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
25
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (72086741..72142259, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (72086741..72142259, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat-containing protein family member 7 Neighboring gene proline rich 16 Neighboring gene TNF alpha induced protein 8 Neighboring gene Dmx like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of 17 beta-hydroxysteroid dehydrogenase type IV in chick retinal pigment epithelium. Kobayashi K, et al. Exp Eye Res, 1997 May. PMID 9245902
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peroxisomal multifunctional enzyme type 2
Names
17-beta-hydroxysteroid dehydrogenase type IV
NP_990274.1
XP_015136074.1
XP_040511354.1
XP_046790759.1
XP_046790760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204943.2 → NP_990274.1  peroxisomal multifunctional enzyme type 2

    See identical proteins and their annotated locations for NP_990274.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000096
    UniProtKB/TrEMBL
    A0A8V0Y590, E1BW32, O42484
    Related
    ENSGALP00010012678.1, ENSGALT00010022105.1
    Conserved Domains (6) summary
    PLN02864
    Location:316 → 605
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:5 → 254
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    PRK05653
    Location:6 → 226
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
    cd03448
    Location:485 → 605
    HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
    pfam02036
    Location:627 → 730
    SCP2; SCP-2 sterol transfer family
    cl00509
    Location:376 → 449
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    72086741..72142259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655420.2 → XP_040511354.1  peroxisomal multifunctional enzyme type 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y590
    Conserved Domains (3) summary
    PLN02864
    Location:179 → 468
    PLN02864; enoyl-CoA hydratase
    cl01225
    Location:533 → 598
    SCP2; SCP-2 sterol transfer family
    cl21454
    Location:1 → 117
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_015280588.4 → XP_015136074.1  peroxisomal multifunctional enzyme type 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5NWL9, A0A8V0Y590
    Related
    ENSGALP00010012677.1, ENSGALT00010022101.1
    Conserved Domains (6) summary
    PLN02864
    Location:306 → 595
    PLN02864; enoyl-CoA hydratase
    cd05353
    Location:11 → 244
    hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs
    PRK12825
    Location:2 → 233
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    cd03448
    Location:475 → 595
    HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.
    pfam02036
    Location:617 → 720
    SCP2; SCP-2 sterol transfer family
    cl00509
    Location:366 → 439
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    72086741..72142259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934804.1 → XP_046790760.1  peroxisomal multifunctional enzyme type 2 isoform X2

  2. XM_046934803.1 → XP_046790759.1  peroxisomal multifunctional enzyme type 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5NWL9
Nucleotide Protein
Heading Accession and Version

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