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NPPA natriuretic peptide A [ Gallus gallus (chicken) ]

Gene ID: 395765, updated on 17-Aug-2024

Summary

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Symbol
NPPAprovided by CGNC
Full Name
natriuretic peptide Aprovided by CGNC
Primary source
CGNC:49466
See related
Ensembl:ENSGALG00010022146
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ANF; ANP; NPPB
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Genomic context

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See NPPA in Genome Data Viewer
Location:
chromosome: 21
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (5570001..5572642)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (5604079..5606719)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene C-type natriuretic peptide 3 Neighboring gene renal natriuretic peptide Neighboring gene chloride voltage-gated channel 6 Neighboring gene methylenetetrahydrofolate reductase Neighboring gene chromosome 1 open reading frame 167 Neighboring gene angiotensin II receptor associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a 29-amino acid natriuretic peptide in chicken heart. Miyata A, et al. Biochem Biophys Res Commun, 1988 Sep 30. PMID 2972278
  2. Cloning and sequence analysis of complementary DNA encoding a precursor for chicken natriuretic peptide. Akizuki N, et al. FEBS Lett, 1991 Mar 25. PMID 1826483
  3. Brain Natriuretic Peptide Stimulates Lipid Metabolism through Its Receptor NPR1 and the Glycerolipid Metabolism Pathway in Chicken Adipocytes. Huang HY, et al. Biochemistry, 2015 Nov 3. PMID 26463554
  4. Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken. Houweling AC, et al. Dev Dyn, 2005 Jul. PMID 15895405
  5. Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Yazawa S, et al. Dev Dyn, 2003 Jan. PMID 12508222

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
natriuretic peptides B
Names
atrial natriuretic factor
atrial natriuretic peptide
natriuretic peptide B
natriuretic peptide precursor A
natriuretic peptides A
prepronatriodilatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204925.1 → NP_990256.1  natriuretic peptides B precursor

    See identical proteins and their annotated locations for NP_990256.1

    Status: PROVISIONAL

    Source sequence(s)
    X57702
    UniProtKB/Swiss-Prot
    P18908
    Related
    ENSGALP00010032434.1, ENSGALT00010053868.1
    Conserved Domains (1) summary
    pfam00212
    Location:104 → 134
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5570001..5572642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040651099.2 → XP_040507033.1  natriuretic peptides B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZUA3
    Related
    ENSGALP00010032433.1, ENSGALT00010053867.1
    Conserved Domains (1) summary
    smart00183
    Location:111 → 134
    NAT_PEP; Natriuretic peptide

  2. XM_046903104.1 → XP_046759060.1  natriuretic peptides B isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5604079..5606719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931145.1 → XP_046787101.1  natriuretic peptides B isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZUA3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18908.2 GenPept UniProtKB/Swiss-Prot:P18908

Gene LinkOut

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