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ETV4 ETS variant 4 [ Gallus gallus (chicken) ]

Gene ID: 395747, updated on 17-Aug-2024

Summary

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Symbol
ETV4provided by CGNC
Full Name
ETS variant 4provided by CGNC
Primary source
CGNC:807
See related
Ensembl:ENSGALG00010024333
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PEA3
Orthologs
human mouse all
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Genomic context

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See ETV4 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 27 NC_052558.1 (3160578..3174795)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 27 NC_052599.1 (4292227..4306478)

Chromosome 27 - NC_052558.1Genomic Context describing neighboring genes Neighboring gene sclerostin Neighboring gene mesenchyme homeobox 1 Neighboring gene DEAH-box helicase 8 Neighboring gene prohibitin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pea3 expression is regulated by FGF signaling in developing retina. McCabe KL, et al. Dev Dyn, 2006 Feb. PMID 16273524, Free PMC Article
  2. Pax2 and Pea3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear. Barembaum M, et al. Dev Biol, 2010 Apr 15. PMID 19913005, Free PMC Article
  3. Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Lin JH, et al. Cell, 1998 Oct 30. PMID 9814709
  4. FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Brent AE, et al. Development, 2004 Aug. PMID 15253939

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PEA3 and PAX2 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear.
    Title: Pax2 and Pea3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear.
  2. Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation
    Title: Pea3 expression is regulated by FGF signaling in developing retina.
  3. Along with erm, activates Scx expression in response to FGF.
    Title: FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ETS translocation variant 4
Names
ets domain protein
ets variant gene 4 (E1A enhancer binding protein, E1AF)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052558.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3160578..3174795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015299450.4 → XP_015154936.1  ETS translocation variant 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A142
    Related
    ENSGALP00010036219.1, ENSGALT00010059338.1
    Conserved Domains (2) summary
    smart00413
    Location:300 → 384
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 299
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. XM_015299451.4 → XP_015154937.1  ETS translocation variant 4 isoform X2

    Conserved Domains (2) summary
    smart00413
    Location:299 → 383
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 298
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  3. XM_015299452.4 → XP_015154938.1  ETS translocation variant 4 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:299 → 383
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 298
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  4. XM_040653290.2 → XP_040509224.1  ETS translocation variant 4 isoform X4

    Conserved Domains (1) summary
    smart00413
    Location:298 → 382
    ETS; erythroblast transformation specific domain

  5. XM_046904454.1 → XP_046760410.1  ETS translocation variant 4 isoform X5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052599.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4292227..4306478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040691928.2 → XP_040547862.1  ETS translocation variant 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A142
    Conserved Domains (2) summary
    smart00413
    Location:300 → 384
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 299
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. XM_040691930.2 → XP_040547864.1  ETS translocation variant 4 isoform X2

    Conserved Domains (2) summary
    smart00413
    Location:299 → 383
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 298
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  3. XM_040691931.2 → XP_040547865.1  ETS translocation variant 4 isoform X3

    Conserved Domains (2) summary
    smart00413
    Location:299 → 383
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:3 → 298
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  4. XM_040691932.2 → XP_040547866.1  ETS translocation variant 4 isoform X4

    Conserved Domains (1) summary
    smart00413
    Location:298 → 382
    ETS; erythroblast transformation specific domain

  5. XM_046933541.1 → XP_046789497.1  ETS translocation variant 4 isoform X5

Nucleotide Protein
Heading Accession and Version

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