MMP13 matrix metallopeptidase 13 [Gallus gallus (chicken)] - Gene

Summary

Symbol: MMP13provided by CGNC
Full Name: matrix metallopeptidase 13provided by CGNC
Primary source: CGNC:49430
See related: Ensembl:ENSGALG00010007330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MMP-13
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (182278268..182285583)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (182319512..182326813)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Age-related changes of MMP-13 with balance of TIMPs act in concert to effect the controlled testicular remodeling and maturation.
Title: Expression of matrix metalloproteinase-13 (MMP-13) in the testes of growing and adult chicken.
plays a role in the vascularization and ossification processes
Title: Expression of matrix metalloproteinases during vascularization and ossification of normal and impaired avian growth plate.
These findings collectively show for the first time that multiple MMPs, ADAMs, and TIMPs appear to functionally interact during corneal development.
Title: Roles of MMP/TIMP in regulating matrix swelling and cell migration during chick corneal development.
MMP-13 associates with collagen remodeling involved in the angiogenic cascade.
Title: Collagenolysis-dependent angiogenesis mediated by matrix metalloproteinase-13 (collagenase-3).

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: collagenase 3

Names: matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase-13

NP_001280019.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293090.2 → NP_001280019.2 collagenase 3 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000027

UniProtKB/TrEMBL

A0A7L8YSP2, A0A8V0Y0B3

Related

ENSGALP00010009666.1, ENSGALT00010017483.1

Conserved Domains (3) summary

cd00094
Location:281 → 471

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:112 → 267

Peptidase_M10; Matrixin

pfam01471
Location:32 → 91

PG_binding_1; Putative peptidoglycan binding domain