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ERBB4 erb-b2 receptor tyrosine kinase 4 [ Gallus gallus (chicken) ]

Gene ID: 395671, updated on 10-Oct-2024

Summary

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Symbol
ERBB4provided by CGNC
Full Name
erb-b2 receptor tyrosine kinase 4provided by CGNC
Primary source
CGNC:49428
See related
Ensembl:ENSGALG00010011625
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See ERBB4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
32
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (3133650..3625134, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (3074777..3566088, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111314 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene uncharacterized LOC107053789 Neighboring gene IKAROS family zinc finger 2 Neighboring gene uncharacterized LOC107053787

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distribution of neuregulin-1 (nrg1) and erbB4 transcripts in embryonic chick hindbrain. Dixon M, et al. Mol Cell Neurosci, 1999 Apr. PMID 10328884

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-4
Names
ovarian receptor tyrosine kinase erbB4 precusor
receptor tyrosine kinase
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NP_001025536.1
XP_015144601.1
XP_015144603.1
XP_015144604.1
XP_040559246.1
XP_040559247.1
XP_040559248.1
XP_046776971.1
XP_046776972.1
XP_046776973.1
XP_046776974.1
XP_046776975.1
XP_046776976.1
XP_046776977.1
XP_046799379.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030365.1 → NP_001025536.1  receptor tyrosine-protein kinase erbB-4

    See identical proteins and their annotated locations for NP_001025536.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ069276
    UniProtKB/TrEMBL
    A0A8V0YBW2, Q4PLA4
    Related
    ENSGALP00010015950.1, ENSGALT00010027816.1
    Conserved Domains (8) summary
    cd05110
    Location:697 → 999
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:629 → 672
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:536 → 583
    FU; Furin-like repeats
    cd00064
    Location:216 → 261
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:173 → 319
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:42 → 154
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:705 → 961
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:489 → 621
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3133650..3625134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015289117.4 → XP_015144603.1  receptor tyrosine-protein kinase erbB-4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YAF6
    Conserved Domains (8) summary
    cd05110
    Location:714 → 1016
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:646 → 689
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:553 → 600
    FU; Furin-like repeats
    cd00064
    Location:233 → 278
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:190 → 336
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:59 → 171
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:722 → 978
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:506 → 638
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_015289115.4 → XP_015144601.1  receptor tyrosine-protein kinase erbB-4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YAE2
    Conserved Domains (8) summary
    cd05110
    Location:714 → 1016
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:646 → 689
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:553 → 600
    FU; Furin-like repeats
    cd00064
    Location:233 → 278
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:190 → 336
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:59 → 171
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:722 → 978
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:506 → 638
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_015289118.4 → XP_015144604.1  receptor tyrosine-protein kinase erbB-4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YAF6, A0A8V0YE48
    Related
    ENSGALP00010015964.1, ENSGALT00010027838.1
    Conserved Domains (8) summary
    cd05110
    Location:704 → 1006
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:636 → 679
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:553 → 600
    FU; Furin-like repeats
    cd00064
    Location:233 → 278
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:190 → 336
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:59 → 171
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:712 → 968
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:506 → 637
    GF_recep_IV; Growth factor receptor domain IV

  4. XM_040703312.2 → XP_040559246.1  receptor tyrosine-protein kinase erbB-4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YAE2
    Conserved Domains (4) summary
    cd05110
    Location:704 → 1006
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:636 → 679
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:553 → 600
    FU; Furin-like repeats
    cd00064
    Location:233 → 278
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

  5. XM_046943423.1 → XP_046799379.1  receptor tyrosine-protein kinase erbB-4 isoform X5

  6. XM_040703313.2 → XP_040559247.1  receptor tyrosine-protein kinase erbB-4 isoform X7

    UniProtKB/TrEMBL
    A0A8V0YAE2
    Conserved Domains (4) summary
    cd05110
    Location:645 → 947
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:577 → 620
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:484 → 531
    FU; Furin-like repeats
    cd00064
    Location:164 → 209
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

  7. XM_040703314.2 → XP_040559248.1  receptor tyrosine-protein kinase erbB-4 isoform X6

    UniProtKB/TrEMBL
    Q9W6F6
    Conserved Domains (4) summary
    cd05110
    Location:461 → 763
    PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4
    cd12092
    Location:393 → 436
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    smart00261
    Location:300 → 347
    FU; Furin-like repeats
    cd00064
    Location:254 → 304
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3074777..3566088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921017.1 → XP_046776973.1  receptor tyrosine-protein kinase erbB-4 isoform X3

  2. XM_046921015.1 → XP_046776971.1  receptor tyrosine-protein kinase erbB-4 isoform X1

  3. XM_046921018.1 → XP_046776974.1  receptor tyrosine-protein kinase erbB-4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YE48

  4. XM_046921016.1 → XP_046776972.1  receptor tyrosine-protein kinase erbB-4 isoform X2

  5. XM_046921020.1 → XP_046776976.1  receptor tyrosine-protein kinase erbB-4 isoform X5

  6. XM_046921019.1 → XP_046776975.1  receptor tyrosine-protein kinase erbB-4 isoform X8

  7. XM_046921021.1 → XP_046776977.1  receptor tyrosine-protein kinase erbB-4 isoform X6

Nucleotide Protein
Heading Accession and Version

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