DUSP4 dual specificity phosphatase 4 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: DUSP4provided by CGNC
Official Full Name: dual specificity phosphatase 4provided by CGNC
Primary source: CGNC:8678
See related: Ensembl:ENSGALG00010002994
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MKP-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (48873646..48878752)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (48878876..48884001)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in endoderm formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 4

Names: MAP kinase phosphatase 2; mitogen-activated protein kinase phosphatase 2

NP_990169.2

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204838.2 → NP_990169.2 dual specificity protein phosphatase 4

Status: PROVISIONAL

Source sequence(s)

JAENSK010000074

UniProtKB/Swiss-Prot

Q9PW71

UniProtKB/TrEMBL

F1NCC5

Related

ENSGALP00010004244.1, ENSGALT00010006981.1

Conserved Domains (2) summary

cd01446
Location:9 → 142

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14640
Location:177 → 317

DSP_DUSP4; dual specificity phosphatase domain of dual specificity protein phosphatase 4