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CHRNA4 cholinergic receptor nicotinic alpha 4 subunit [ Gallus gallus (chicken) ]

Gene ID: 395606, updated on 17-Aug-2024

Summary

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Symbol
CHRNA4provided by CGNC
Full Name
cholinergic receptor nicotinic alpha 4 subunitprovided by CGNC
Primary source
CGNC:49398
See related
Ensembl:ENSGALG00010023162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NACHRA4
Orthologs
human mouse all
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Genomic context

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See CHRNA4 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (9213274..9232985, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (8995227..9014923, complement)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene collagen type XX alpha 1 chain Neighboring gene potassium voltage-gated channel subfamily Q member 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. Anand R, et al. J Biol Chem, 1991 Jun 15. PMID 2040627
  2. Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Cooper E, et al. Nature, 1991 Mar 21. PMID 2005979
  3. Nicotinic receptor subtypes in the developing chick brain: appearance of a species containing the alpha4, beta2, and alpha5 gene products. Conroy WG, et al. Mol Pharmacol, 1998 Mar. PMID 9495803
  4. Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype. Balestra B, et al. Mol Pharmacol, 2000 Aug. PMID 10908297
  5. Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors. Nef P, et al. EMBO J, 1988 Mar. PMID 3267226, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neuronal acetylcholine receptor subunit alpha-4
Names
alpha-4 subunit, nicotinic acetylcholine receptor
cholinergic receptor, nicotinic, alpha 4 (neuronal)
cholinergic receptor, nicotinic, alpha polypeptide 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397350.1 → NP_001384279.1  neuronal acetylcholine receptor subunit alpha-4 precursor

    Status: VALIDATED

    Source sequence(s)
    AJ250361, BU232281, BU354330, BX931114, HAEK01001429, HAEK01012059, HAEK01048206, HAEK01087938, JAENSK010000328
    UniProtKB/Swiss-Prot
    P09482
    UniProtKB/TrEMBL
    A0A8V0ZLF1
    Related
    ENSGALP00010034200.1, ENSGALT00010056457.1
    Conserved Domains (3) summary
    cd03558
    Location:156 → 170
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:32 → 238
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    pfam02932
    Location:245 → 613
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  2. NM_204814.1 → NP_990145.1  neuronal acetylcholine receptor subunit alpha-4 precursor

    See identical proteins and their annotated locations for NP_990145.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ250361
    UniProtKB/Swiss-Prot
    P09482
    UniProtKB/TrEMBL
    A0A8V0ZLF1
    Conserved Domains (3) summary
    cd03558
    Location:156 → 170
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:32 → 238
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    pfam02932
    Location:245 → 613
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9213274..9232985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8995227..9014923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09482.1 GenPept UniProtKB/Swiss-Prot:P09482

Gene LinkOut

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