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TEAD4 TEA domain transcription factor 4 [ Gallus gallus (chicken) ]

Gene ID: 395542, updated on 12-Oct-2024

Summary

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Symbol
TEAD4provided by CGNC
Full Name
TEA domain transcription factor 4provided by CGNC
Primary source
CGNC:49367
See related
Ensembl:ENSGALG00010024709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TEF3; TEF-1; TEF-3; RTEF-1; TEAD-4
Summary
This gene encodes a transcription factor which is a member of the transcriptional enhancer factor (TEF) family. Members of this family are characterized by a TEA/ATTS DNA-binding domain. This factor, which is highly expressed in muscle, binds to a promoter element called M-CAT, a motif found in promoters of muscle specific genes. Alternatively spliced transcripts encoding distinct isoforms, which are encoded through the use of a non-AUG (UUG) translation initiation codon, have been described. [provided by RefSeq, Jul 2008]
Orthologs
human mouse all
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Genomic context

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See TEAD4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (75504414..75571631, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (75715417..75782671, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 11 Neighboring gene tetraspanin 9 Neighboring gene uncharacterized LOC124417652 Neighboring gene uncharacterized LOC124417656 Neighboring gene uncharacterized LOC121109408 Neighboring gene forkhead box M1 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene TUB like protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues. Farrance IK, et al. J Biol Chem, 1996 Apr 5. PMID 8626521
  2. Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. Stewart AF, et al. J Biol Chem, 1994 Feb 4. PMID 8106348
  3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in embryonic organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcriptional enhancer factor TEF-3
Names
M-CAT binding factor
TEA domain family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001337.2 → NP_001001337.1  transcriptional enhancer factor TEF-3 isoform 1

    See identical proteins and their annotated locations for NP_001001337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also referred to as TEF-1A', differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    JAENSK010000015
    UniProtKB/TrEMBL
    A0A1D5PGA5
    Conserved Domains (1) summary
    smart00426
    Location:37 → 104
    TEA; TEA domain

  2. NM_001001340.2 → NP_001001340.1  transcriptional enhancer factor TEF-3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also referred to as TEF-1D, lacks a segment in the 5' coding region, compared to variant 1. Translation of this transcript does not begin at a non-AUG translation initiation codon, compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BU320294, BX932327, U06851
    UniProtKB/TrEMBL
    A0A8V1A1M3

  3. NM_001001341.1 → NP_001001341.1  transcriptional enhancer factor TEF-3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame segment, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1.
    Source sequence(s)
    U04834
    UniProtKB/TrEMBL
    F1NIL6
    Related
    ENSGALP00010037096.1, ENSGALT00010060337.1
    Conserved Domains (1) summary
    smart00426
    Location:37 → 104
    TEA; TEA domain

  4. NM_001306152.3 → NP_001293081.1  transcriptional enhancer factor TEF-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    JAENSK010000015
    UniProtKB/TrEMBL
    F1NIL7
    Related
    ENSGALP00010037104.1, ENSGALT00010060345.1
    Conserved Domains (2) summary
    smart00426
    Location:37 → 104
    TEA; TEA domain
    pfam17725
    Location:233 → 442
    YBD; YAP binding domain

  5. NM_001359859.1 → NP_001346788.1  transcriptional enhancer factor TEF-3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    BX932327, HAEL01010157, U06849
    UniProtKB/TrEMBL
    A0A1D5PPT8
    Related
    ENSGALP00010037090.1, ENSGALT00010060331.1
    Conserved Domains (1) summary
    smart00426
    Location:37 → 104
    TEA; TEA domain

  6. NM_204771.1 → NP_990102.1  transcriptional enhancer factor TEF-3 isoform 1

    See identical proteins and their annotated locations for NP_990102.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also referred to as TEF-1A, encodes the predominant isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    U04834
    UniProtKB/TrEMBL
    A0A1D5PGA5
    Related
    ENSGALP00010037111.1, ENSGALT00010060352.1
    Conserved Domains (1) summary
    smart00426
    Location:37 → 104
    TEA; TEA domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    75504414..75571631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    75715417..75782671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001338.1: Suppressed sequence

    Description
    NM_001001338.1: This RefSeq was permanently suppressed because it contains the wrong CDS.

  2. NM_001001339.1: Suppressed sequence

    Description
    NM_001001339.1: This RefSeq has been removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48984.1 GenPept UniProtKB/Swiss-Prot:P48984

Gene LinkOut

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