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endos endosulfine [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39554, updated on 2-Nov-2024

Summary

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Official Symbol
endosprovided by FlyBase
Official Full Name
endosulfineprovided by FlyBase
Primary source
FLYBASE:FBgn0061515
Locus tag
Dmel_CG6513
See related
AllianceGenome:FB:FBgn0061515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0670/06; CG6513; dendos; Dmel\CG6513; End; Endos; ENSA; l(3)S067006
Summary
Enables protein phosphatase inhibitor activity. Involved in several processes, including regulation of meiotic cell cycle; regulation of mitotic nuclear division; and response to nutrient. Predicted to be active in cytoplasm. Is expressed in Malpighian tubule; adult head; embryonic/larval proventriculus; and larval brain. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19) and ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See endos in Genome Data Viewer
Location:
70C14-70C15; 3-41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14029579..14031706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14022679..14024806, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein Neighboring gene antisense RNA:CR42871 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 110

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alpha-endosulfine, a potential regulator of insulin secretion, is required for adult tissue growth control in Drosophila. Drummond-Barbosa D, et al. Dev Biol, 2004 Feb 15. PMID 14738879
  2. Greatwall-Endos-PP2A/B55(Twins) network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition. Rangone H, et al. Open Biol, 2024 Jun. PMID 38896085, Free PMC Article
  3. A Genetic Screen for Dominant Enhancers of the Cell-Cycle Regulator α-Endosulfine Identifies Matrimony as a Strong Functional Interactor in Drosophila. Von Stetina JR, et al. G3 (Bethesda), 2011 Dec. PMID 22384372, Free PMC Article
  4. Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle. Wang P, et al. Cell Cycle, 2016. PMID 26761639, Free PMC Article
  5. Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression. Larouche M, et al. J Cell Biol, 2021 Jun 7. PMID 33836042, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Greatwall-Endos-PP2A/B55[Twins] network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.
    Title: Greatwall-Endos-PP2A/B55(Twins) network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition.
  2. This mechanism explains simultaneously how PP2A-B55 and Gwl together regulate phosphorylated Endos, and how phosphorylated Endos controls PP2A-B55.
    Title: Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.
  3. Greatwall phosphorylates Endos at a single site, Ser68, and this is essential for Endos function
    Title: Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis.
  4. Endos controls meiotic maturation by regulating Twine and Polo levels, and, independently, by antagonizing Elgi
    Title: alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila.
  5. Data suggest that the Drosophila alpha-endosulfine (dendos) gene is required for the proliferative response of ovarian cells to nutritional changes.
    Title: Alpha-endosulfine, a potential regulator of insulin secretion, is required for adult tissue growth control in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nutrient IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endosulfine
Names
CG6513-PA
CG6513-PB
CG6513-PC
CG6513-PD
CG6513-PE
CG6513-PF
alpha-endosulfine
dendos
endos-PA
endos-PB
endos-PC
endos-PD
endos-PE
endos-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14029579..14031706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274891.1 → NP_001261820.1  endosulfine, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  2. NM_140427.3 → NP_648684.1  endosulfine, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Related
    FBpp0099872
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  3. NM_001274892.1 → NP_001261821.1  endosulfine, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  4. NM_001259816.2 → NP_001246745.1  endosulfine, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  5. NM_001259817.2 → NP_001246746.1  endosulfine, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  6. NM_168572.2 → NP_729949.1  endosulfine, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729949.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUB8
    Related
    FBpp0099873
    Conserved Domains (1) summary
    pfam04667
    Location:33 → 117
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUB8 Q9VUB8

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