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Nprl3 Nitrogen permease regulator-like 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39550, updated on 2-Nov-2024

Summary

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Official Symbol
Nprl3provided by FlyBase
Official Full Name
Nitrogen permease regulator-like 3provided by FlyBase
Primary source
FLYBASE:FBgn0036397
Locus tag
Dmel_CG8783
See related
AllianceGenome:FB:FBgn0036397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8783; Dmel\CG8783; GATOR1; Nplr3; NPR3; nprl3
Summary
Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and negative regulation of cell size. Located in autolysosome and nucleus. Part of GATOR2 complex. Is expressed in organism. Used to study familial focal epilepsy with variable foci 3. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nprl3 in Genome Data Viewer
Location:
70C11-70C11; 3-41 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13999380..14001880, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13992480..13994980, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cathepsin K1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity. Cheng Y, et al. Biol Open, 2020 Nov 6. PMID 33037015, Free PMC Article
  2. Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy. Du S, et al. Sci China Life Sci, 2023 Sep. PMID 37071290
  3. The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Wei Y, et al. Cell Death Differ, 2014 Sep. PMID 24786828, Free PMC Article
  4. The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster. Wei Y, et al. G3 (Bethesda), 2016 Dec 7. PMID 27672113, Free PMC Article
  5. TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. Wei Y, et al. Proc Natl Acad Sci U S A, 2014 Dec 30. PMID 25512509, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy.
    Title: Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy.
  2. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
    Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germarium-derived egg chamber formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GATOR1 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of GATOR2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Seh1-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Seh1-associated complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in autolysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nitrogen permease regulator-like 3
Names
CG8783-PA
CG8783-PB
CG8783-PC
Nprl3-PA
Nprl3-PB
Nprl3-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13999380..14001880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168570.1 → NP_729945.1  nitrogen permease regulator-like 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729945.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1X9, Q95RI3, Q9VUB4
    UniProtKB/TrEMBL
    B6IDY8
    Related
    FBpp0075527, FBtr0075785
    Conserved Domains (1) summary
    cl24021
    Location:76 → 413
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  2. NM_140423.3 → NP_648680.2  nitrogen permease regulator-like 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648680.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1X9, Q95RI3, Q9VUB4
    UniProtKB/TrEMBL
    B6IDY8
    Related
    FBpp0075528
    Conserved Domains (1) summary
    cl24021
    Location:76 → 413
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  3. NM_001274889.1 → NP_001261818.1  nitrogen permease regulator-like 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1X9, Q95RI3, Q9VUB4
    UniProtKB/TrEMBL
    B6IDY8
    Conserved Domains (1) summary
    cl24021
    Location:76 → 413
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6IDY8 B6IDY8
Q9VUB4.1 Q9VUB4

Gene LinkOut

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