Hml Hemolectin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hmlprovided by FlyBase
Official Full Name: Hemolectinprovided by FlyBase
Primary source: FLYBASE:FBgn0029167
Locus tag: Dmel_CG7002
See related: AllianceGenome:FB:FBgn0029167
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7002; CT21553; d-hml; Dmel\CG7002; hml
Summary: Enables protein homodimerization activity. Involved in hemolymph coagulation. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; cortical zone of lymph gland primary lobe; embryonic/larval hemolymph; and hemocyte. Human ortholog(s) of this gene implicated in asthma; dry eye syndrome; lung disease (multiple); and urinary bladder cancer. Orthologous to several human genes including SSPOP (SCO-spondin, pseudogene); MUC2 (mucin 2, oligomeric mucus/gel-forming); and MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 70C4-70C5; 3-41 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (13846054..13860001)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (13839154..13853101)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study describes the isolation of a new hml allele in a forward screen for coagulation mutants, and characterization of this and two other hml alleles; findings demonstrate an immunological role of hemolectin
Title: A role for Hemolectin in coagulation and immunity in Drosophila melanogaster.
Data from an experiment demonstrating the inducible expression of Hml double-stranded RNA (dsRNA) indicate that a slow rate of engulfment of larval cells results in a longer time to emergence.
Title: Exposure to low-dose X-rays promotes peculiar autophagic cell death in Drosophila melanogaster, an effect that can be regulated by the inducible expression of Hml dsRNA.
Hemolectin(Hml) is involved in hemostasis and/or coagulation in Drosophila larvae.
Title: Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0129 (e-PCR)
- UniSTS:28877

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in hemolymph coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hemolectin

Names: CG7002-PA; CG7002-PB; Hml-PA; Hml-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

13846054..13860001

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079336.3 → NP_524060.2 hemolectin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524060.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9U5D0, Q9VU94

Related

FBpp0075495

Conserved Domains (10) summary

smart00216
Location:840 → 1015

VWD; von Willebrand factor (vWF) type D domain

smart00231
Location:2299 → 2404

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

smart00832
Location:1054 → 1121

C8; This domain contains 8 conserved cysteine residues

cd00057
Location:2089 → 2223

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam01826
Location:1131 → 1185

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:3257 → 3313

C8; C8 domain

pfam13330
Location:1751 → 1837

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

cl02516
Location:3035 → 3198

VWD; von Willebrand factor type D domain

cl17735
Location:3397 → 3451

VWC; von Willebrand factor type C domain

cl21545
Location:3755 → 3813

GHB_like; Glycoprotein hormone beta chain homologues
NM_001274880.1 → NP_001261809.1 hemolectin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261809.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCE5, Q9U5D0

Conserved Domains (10) summary

smart00216
Location:839 → 1014

VWD; von Willebrand factor (vWF) type D domain

smart00231
Location:2298 → 2403

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

smart00832
Location:1053 → 1120

C8; This domain contains 8 conserved cysteine residues

cd00057
Location:2088 → 2222

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam01826
Location:1130 → 1184

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:3256 → 3312

C8; C8 domain

pfam13330
Location:1750 → 1836

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

cl02516
Location:3034 → 3197

VWD; von Willebrand factor type D domain

cl17735
Location:3396 → 3450

VWC; von Willebrand factor type C domain

cl21545
Location:3754 → 3812

GHB_like; Glycoprotein hormone beta chain homologues