U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NODAL nodal growth differentiation factor [ Gallus gallus (chicken) ]

Gene ID: 395205, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
NODALprovided by CGNC
Full Name
nodal growth differentiation factorprovided by CGNC
Primary source
CGNC:49212
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NODAL in Genome Data Viewer
Location:
chromosome: 22
Exon count:
2
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 22 NC_052553.1 (2426550..2428532, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 22 NC_052594.1 (2473855..2475875, complement)

Chromosome 22 - NC_052553.1Genomic Context describing neighboring genes Neighboring gene nucleoplasmin-like Neighboring gene adrenoceptor beta 3 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene steroidogenic acute regulatory protein Neighboring gene LSM1 homolog, mRNA degradation associated

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm. Ellis PS, et al. Development, 2015 Nov 15. PMID 26417042, Free PMC Article
  2. A role for Vg1/Nodal signaling in specification of the intermediate mesoderm. Fleming BM, et al. Development, 2013 Apr. PMID 23533180, Free PMC Article
  3. Nodal signal is required for morphogenetic movements of epiblast layer in the pre-streak chick blastoderm. Yanagawa N, et al. Dev Growth Differ, 2011 Apr. PMID 21492150
  4. Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist. Matsui H, et al. Dev Dyn, 2005 Aug. PMID 15977172
  5. The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling. Bertocchini F, et al. Dev Cell, 2002 Nov. PMID 12431379

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.
    Title: ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.
  2. Double inhibition of NODAL and SHH pathways from the onset of gastrulation promotes holoprosencephaly.
    Title: NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos.
  3. Nodal-like signaling regulates intermediate mesoderm (IM) formation by modulating the IM-inducing effects of BMP signaling.
    Title: A role for Vg1/Nodal signaling in specification of the intermediate mesoderm.
  4. different levels of BMP signaling regulate Nodal expression by a balance between BMP-pSMAD1/4 signaling and NODAL-pSMAD2/4 signaling
    Title: Multi-modal effects of BMP signaling on Nodal expression in the lateral plate mesoderm during left-right axis formation in the chick embryo.
  5. Nodal signaling may have a pivotal role in the morphogenetic movements of epithelial epiblast including Polonaise movements and formation of multi-cellular rosette.
    Title: Nodal signal is required for morphogenetic movements of epiblast layer in the pre-streak chick blastoderm.
  6. BMP signaling is necessary and sufficient for the induction of Nodal expression in the chick lateral plate mesoderm
    Title: Cerberus functions as a BMP agonist to synergistically induce nodal expression during left-right axis determination in the chick embryo.
  7. FGF8b & Nodal, but neither factor alone induced SMA & heart specific markers in cultured epiblast. FGF8b acts on the epiblast synergistically with Nodal at the pregastrula stage.
    Title: Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8.
  8. May play an important role in the regulation of smooth muscle actin expression
    Title: Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type I activin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nodal homolog
Names
nodal-related protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2426550..2428532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040651526.1 → XP_040507460.1  nodal homolog

    UniProtKB/TrEMBL
    A0A8V0YWE7
    Conserved Domains (1) summary
    cd13759
    Location:175 → 276
    TGF_beta_NODAL; transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2473855..2475875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040689359.1 → XP_040545293.1  nodal homolog

    UniProtKB/TrEMBL
    A0A8V0YWE7
    Conserved Domains (1) summary
    cd13759
    Location:175 → 276
    TGF_beta_NODAL; transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials