HS2ST1 heparan sulfate 2-O-sulfotransferase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: HS2ST1provided by CGNC
Full Name: heparan sulfate 2-O-sulfotransferase 1provided by CGNC
Primary source: CGNC:66193
See related: Ensembl:ENSGALG00010023030
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HS2ST; CHS2ST
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (15559264..15631433, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (15567700..15639895, complement)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase.
Title: Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase.
Results report the homotrimeric crystal structure of 2OST from chicken, in complex with 3'-phosphoadenosine 5'-phosphate, and identify amino acid residues that are responsible for substrate specificity.
Title: Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis.
study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud
Title: Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heparan sulfate 2-O-sulfotransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heparan sulfate 2-O-sulfotransferase 1

NP_989812.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204481.2 → NP_989812.1 heparan sulfate 2-O-sulfotransferase 1

See identical proteins and their annotated locations for NP_989812.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000239

UniProtKB/Swiss-Prot

Q76KB1

UniProtKB/TrEMBL

A0A8V0ZTW6

Related

ENSGALP00010033929.1, ENSGALT00010056080.1

Conserved Domains (1) summary

pfam03567
Location:71 → 326

Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

15559264..15631433 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

15567700..15639895 complement

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GenBank, FASTA, Sequence Viewer (Graphics)