CDKN2B cyclin dependent kinase inhibitor 2B [Gallus gallus (chicken)] - Gene

Summary

Symbol: CDKN2Bprovided by CGNC
Full Name: cyclin dependent kinase inhibitor 2Bprovided by CGNC
Primary source: CGNC:20082
See related: Ensembl:ENSGALG00010001144
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CDKN2A
Summary: This gene encodes a protein similar to one of two mammalian cyclin-dependent kinase inhibitor proteins which regulate the activity of cyclin-dependent protein kinases CDK4 and CDK6 which further cell cycle progression through G1. Expression of this protein in human keratinocytes is induced by TGF-beta, a cytokine that inhibits cell growth through arrest in the G1 phase of the cell cycle. There is evidence that the encoded protein is functionally equivalent to mammalian p16INK4a, a protein from a similar but distinct mammalian gene. [provided by RefSeq, Dec 2008]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (83341829..83345255, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (83341829..83345255, complement)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cell cycle-related gene CDKN2B showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells.
Title: Gene pathways and cell cycle-related genes in cultured avian primordial germ cells.
The study was aimed at identifying the methylation of the CDKN2B gene situated at locus bar in Polbar chickens on the 6th and 18th day of embryonic development using the methylation-specific PCR method.
Title: DNA methylation analysis of the gene CDKN2B in Gallus gallus (chicken).
This novel finding provides the first evidence that the tumour suppressor locus CDKN2A can affect pigmentation phenotypes and sheds new light on the functional significance of this gene.
Title: Sex-linked barring in chickens is controlled by the CDKN2A /B tumour suppressor locus.
The INK4b transcript is expressed in the roof-plate of the developing hind-brain, consistent with a role in limiting cell proliferation.
Title: Upregulation of chicken p15INK4b at senescence and in the developing brain.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase 4 inhibitor B

Names: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); p15INK4b tumor suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204433.2 → NP_989764.1 cyclin-dependent kinase 4 inhibitor B

See identical proteins and their annotated locations for NP_989764.1

Status: REVIEWED

Source sequence(s)

JAENSK010000209

UniProtKB/TrEMBL

Q7ZT27

Related

ENSGALP00010001152.1, ENSGALT00010002602.1

Conserved Domains (3) summary

cd00204
Location:19 → 116

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:19 → 105

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:41 → 71

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

83341829..83345255 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

83341829..83345255 complement

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GenBank, FASTA, Sequence Viewer (Graphics)