hprt1 hypoxanthine phosphoribosyltransferase 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: hprt1provided by Xenbase
Official Full Name: hypoxanthine phosphoribosyltransferase 1provided by Xenbase
Primary source: Xenbase:XB-GENE-1014679
See related: Ensembl:ENSXETG00000019768 AllianceGenome:Xenbase:XB-GENE-1014679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: hprt; hgprt; prtfdc1
Summary: Predicted to enable hypoxanthine phosphoribosyltransferase activity and magnesium ion binding activity. Predicted to be involved in hypoxanthine metabolic process and purine-containing compound salvage. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (68441315..68458866)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (47336586..47354935)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables guanine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in guanine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hypoxanthine-guanine phosphoribosyltransferase

NP_989312.1

EC 2.4.2.8

XP_012823623.2

EC 2.4.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203981.1 → NP_989312.1 hypoxanthine-guanine phosphoribosyltransferase

See identical proteins and their annotated locations for NP_989312.1

Status: PROVISIONAL

Source sequence(s)

BC064242

UniProtKB/TrEMBL

Q28HG9, Q6P2Z2

Related

ENSXETP00000068627.2, ENSXETT00000073664.2

Conserved Domains (1) summary

cl00309
Location:6 → 216

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

68441315..68458866

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012968169.3 → XP_012823623.2 hypoxanthine-guanine phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

A0A8J0SUB9, Q28HG9

Conserved Domains (1) summary

cl00309
Location:21 → 226

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain