mtdh metadherin [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: mtdhprovided by Xenbase
Official Full Name: metadherinprovided by Xenbase
Primary source: Xenbase:XB-GENE-6454651
See related: Ensembl:ENSXETG00000039812 AllianceGenome:Xenbase:XB-GENE-6454651
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: 3d3; aeg1; aeg-1; lyric
Summary: Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (129492752..129505273, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (114438044..114450533, complement)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein LYRIC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203833.1 → NP_989164.1 protein LYRIC

See identical proteins and their annotated locations for NP_989164.1

Status: PROVISIONAL

Source sequence(s)

BC063364

UniProtKB/TrEMBL

A0A6I8SCE6, Q6P4K3

Conserved Domains (1) summary

pfam15686
Location:16 → 406

LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

129492752..129505273 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012964426.2 → XP_012819880.2 protein LYRIC isoform X1

UniProtKB/TrEMBL

A0A6I8S7P1, A0A6I8SCE6

Related

ENSXETP00000089193.2, ENSXETT00000078133.2

Conserved Domains (1) summary

pfam15686
Location:16 → 400

LYRIC; Lysine-rich CEACAM1 co-isolated protein family