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foxa4.S forkhead box A4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394368, updated on 4-Nov-2024

Summary

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Official Symbol
foxa4.S
Official Full Name
forkhead box A4 S homeolog
Primary source
Xenbase:XB-GENE-6254437
Locus tag
XELAEV_18024178mg
See related
EnsemblRapid:ENSXLAG00005008325 AllianceGenome:Xenbase:XB-GENE-6254437
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fkh1; XFD-1; XFKH1; XFKHI; FoxA4a; fkh1-A; foxa4b; xkfh-1; foxa4-a; foxa4-b; pintallavis
Summary
Predicted to enable sequence-specific DNA binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See foxa4.S in Genome Data Viewer
Location:
chromosome: 4S
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (928542..931985)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (910408..913851)

Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene phosphoethanolamine methyltransferase S homeolog Neighboring gene CD248 molecule S homeolog Neighboring gene glutamic acid-rich protein-like Neighboring gene transfer RNA isoleucine (anticodon AAU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos. Kaufmann E, et al. EMBO J, 1996 Dec 2. PMID 8978699, Free PMC Article
  2. Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos. Friedle H, et al. EMBO J, 1998 Apr 15. PMID 9545242, Free PMC Article
  3. A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Dirksen ML, et al. Genes Dev, 1992 Apr. PMID 1559610
  4. Fox (forkhead) genes are involved in the dorso-ventral patterning of the Xenopus mesoderm. El-Hodiri H, et al. Int J Dev Biol, 2001. PMID 11291856
  5. Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos. Knöchel S, et al. Mech Dev, 1992 Aug. PMID 1358174

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC81573

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
forkhead box protein A4-B
Names
FKH-1
fork head domain protein
fork head domain-related protein 1'
forkhead protein 1
xFD-1'

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087607.1 → NP_001081076.1  forkhead box protein A4-B

    See identical proteins and their annotated locations for NP_001081076.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082641
    UniProtKB/Swiss-Prot
    P33206, Q640I4
    UniProtKB/TrEMBL
    A0A974CZJ7
    Related
    ENSXLAP00005023973.1, ENSXLAT00005024681.1
    Conserved Domains (3) summary
    smart00339
    Location:119 → 207
    FH; FORKHEAD
    pfam08430
    Location:33 → 118
    Forkhead_N; Forkhead N-terminal region
    pfam09354
    Location:326 → 388
    HNF_C; HNF3 C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    928542..931985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33206.1 GenPept UniProtKB/Swiss-Prot:P33206

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials