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st14.L suppression of tumorigenicity 14 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394363, updated on 4-Nov-2024

Summary

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Official Symbol
st14.L
Official Full Name
suppression of tumorigenicity 14 L homeolog
Primary source
Xenbase:XB-GENE-1008789
Locus tag
XELAEV_18035255mg
See related
EnsemblRapid:ENSXLAG00005016450 AllianceGenome:Xenbase:XB-GENE-1008789
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hai; st14; mtsp1; snc19; st14a; mt-sp1; prss14; st14-a; st14-b; tadg15; XMT-SP1; tmprss1
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See st14.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (72660156..72697280)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (64206625..64243472)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108696384 Neighboring gene zinc finger and BTB domain containing 44 L homeolog Neighboring gene toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog Neighboring gene zinc finger and BTB domain containing 44 like L homeolog Neighboring gene A disintegrin and metalloproteinase with thrombospondin motifs 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of three novel serine protease genes from Xenopus laevis. Yamada K, et al. Gene, 2000 Jul 11. PMID 10903452
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matriptase a
Names
suppression of tumorigenicity 14 (colon carcinoma) a
suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087597.1 → NP_001081066.1  matriptase a

    See identical proteins and their annotated locations for NP_001081066.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071077
    UniProtKB/TrEMBL
    Q6GR54, Q9DGR1
    Related
    ENSXLAP00005048467.1, ENSXLAT00005049582.1
    Conserved Domains (5) summary
    smart00020
    Location:604 → 839
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:204 → 319
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:513 → 547
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:605 → 842
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:76 → 167
    SEA; SEA domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    72660156..72697280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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