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Pmm2 Phosphomannomutase type 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39436, updated on 2-Nov-2024

Summary

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Official Symbol
Pmm2provided by FlyBase
Official Full Name
Phosphomannomutase type 2provided by FlyBase
Primary source
FLYBASE:FBgn0036300
Locus tag
Dmel_CG10688
See related
AllianceGenome:FB:FBgn0036300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
33589256; CG10688; Dmel\CG10688; pmm2
Summary
Predicted to enable phosphomannomutase activity. Involved in cellular response to hypoxia and protein N-linked glycosylation. Predicted to be active in cytosol. Is expressed in adult head. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM1 (phosphomannomutase 1) and PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Pmm2 in Genome Data Viewer
Location:
69C6-69C6; 3-38 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12534590..12535513)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12527690..12528613)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Transferrin 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43612 Neighboring gene uncharacterized protein Neighboring gene sosondowah Neighboring gene araucan

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. Parkinson WM, et al. Dis Model Mech, 2016 May 1. PMID 26940433, Free PMC Article
  2. A phosphate-sensing organelle regulates phosphate and tissue homeostasis. Xu C, et al. Nature, 2023 May. PMID 37138087, Free PMC Article
  3. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Lee SJ, et al. Mol Biol Cell, 2008 Oct. PMID 18653470, Free PMC Article
  4. A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. Fu Y, et al. Hum Mol Genet, 2017 Feb 15. PMID 28164240, Free PMC Article
  5. Mediation of Drosophila autosomal dosage effects and compensation by network interactions. Malone JH, et al. Genome Biol, 2012 Apr 24. PMID 22531030, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR-generated pmm2-null Drosophila mutants display severely disrupted glycosylation and early lethality.
    Title: Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomannomutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in GDP-mannose biosynthetic process from mannose ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphomannomutase type 2
Names
CG10688-PA
Pmm2-PA
phosphomannomutase-2
NP_648589.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12534590..12535513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140332.2 → NP_648589.1  phosphomannomutase type 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648589.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTZ6
    Related
    FBpp0075693
    Conserved Domains (1) summary
    cd02585
    Location:12 → 251
    HAD_PMM; phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTZ6.1 Q9VTZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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