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elavl2.L ELAV like neuron-specific RNA binding protein 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394342, updated on 11-Apr-2024

Summary

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Official Symbol
elavl2.L
Official Full Name
ELAV like neuron-specific RNA binding protein 2 L homeolog
Primary source
Xenbase:XB-GENE-866091
Locus tag
XELAEV_18006760mg
See related
EnsemblRapid:ENSXLAG00005036432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hub; p45; el-1; elrB; Xel-1; heln1; elavl2; hel-n1; elavl2-a; elavl2-b; elavl2.S
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Genomic context

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See elavl2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (131553864..131658903)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (119254471..119334326)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 2B L homeolog Neighboring gene DMRT like family A1 L homeolog Neighboring gene uncharacterized LOC121401355 Neighboring gene uncharacterized LOC121393942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Misexpression of the RNA-binding protein ELRB in Xenopus presumptive neurectoderm induces proliferation arrest and programmed cell death. Perron M, et al. Int J Dev Biol, 1999 Jul. PMID 10470646
  2. Subcellular distribution of Xenopus XEL-1 protein, a member of the neuron-specific ELAV/Hu family, revealed by epitope tagging. Perron M, et al. DNA Cell Biol, 1997 May. PMID 9174163
  3. Isolation and embryonic expression of Xel-1, a nervous system-specific Xenopus gene related to the elav gene family. Perron M, et al. Mech Dev, 1995 Jun. PMID 7547471
  4. Xenopus ElrB, but not ElrA, binds RNA as an oligomer: possible role of the linker. Devaux A, et al. FEBS Lett, 2006 Sep 4. PMID 16930598
  5. The Xenopus ELAV protein ElrB represses Vg1 mRNA translation during oogenesis. Colegrove-Otero LJ, et al. Mol Cell Biol, 2005 Oct. PMID 16199879, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report on the identification of Xenopus ElrA/B proteins and show that Elr-type proteins are part of one RNP complex together with other localization proteins from Xenopus oocytes.
    Title: Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.
  2. Data show that, while ElrA and ElrB are 69% identical and both exhibit RNA binding in the nM range, recombinant ElrB, but not ElrA, is able to oligomerise.
    Title: Xenopus ElrB, but not ElrA, binds RNA as an oligomer: possible role of the linker.
  3. elrB expression was not detected in Xenopus retina ganglion cell layer until stage 32.
    Title: Comparison of the expression patterns of five neural RNA binding proteins in the Xenopus retina.
  4. direct correlation between ElrB binding and translational repression by the Vg1 3'-UTR
    Title: The Xenopus ELAV protein ElrB represses Vg1 mRNA translation during oogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC197266

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine-rich cytoplasmic polyadenylylation element binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
ELAV-like protein 2
Names
ELAV (embryonic lethal, abnormal vision)-like 2 (Hu antigen B)
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087566.2 → NP_001081035.1  ELAV-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001081035.1

    Status: VALIDATED

    Source sequence(s)
    JAGEVR010000054
    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001088144.2 → NP_001081613.2  ELAV-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAGEVR010000054
    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0

  3. NM_001417058.1 → NP_001403987.1  ELAV-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAGEVR010000054
    UniProtKB/TrEMBL
    A0A974E0E2

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    131553864..131658903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018228686.2 → XP_018084175.1  ELAV-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A974E0E2
    Related
    ENSXLAP00005109069.1, ENSXLAT00005111252.1

  2. XM_041566434.1 → XP_041422368.1  ELAV-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1L046
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  3. XM_041566940.1 → XP_041422874.1  ELAV-like protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A8J1L2T6
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 266
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  4. XM_041566408.1 → XP_041422342.1  ELAV-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1L046
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  5. XM_018228727.2 → XP_018084216.1  ELAV-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1L046
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  6. XM_041566646.1 → XP_041422580.1  ELAV-like protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8J1KZ51
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 385
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  7. XM_018228779.2 → XP_018084268.1  ELAV-like protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8J0TGC8

  8. XM_018228877.2 → XP_018084366.1  ELAV-like protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8J0TGJ6
    Related
    ENSXLAP00005109152.1, ENSXLAT00005111335.1

  9. XM_041566303.1 → XP_041422237.1  ELAV-like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1KY49
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  10. XM_041566556.1 → XP_041422490.1  ELAV-like protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8J1KYV7
    Related
    ENSXLAP00005109148.1, ENSXLAT00005111331.1
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  11. XM_018228496.2 → XP_018083985.1  ELAV-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  12. XM_018228344.2 → XP_018083833.1  ELAV-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. XM_018228410.2 → XP_018083899.1  ELAV-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  14. XM_018228833.2 → XP_018084322.1  ELAV-like protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8J0TEL3

  15. XM_041566609.1 → XP_041422543.1  ELAV-like protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8J1L0M4
    Related
    ENSXLAP00005109143.1, ENSXLAT00005111326.1
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 386
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  16. XM_018228641.2 → XP_018084130.1  ELAV-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q91903
    UniProtKB/TrEMBL
    A0A1L8HY91

  17. XM_018228927.2 → XP_018084416.1  ELAV-like protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8J0TIA1
    Related
    ENSXLAP00005109132.1, ENSXLAT00005111315.1

  18. XM_041566527.1 → XP_041422461.1  ELAV-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1L046
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  19. XM_041566486.1 → XP_041422420.1  ELAV-like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1L046
    Conserved Domains (1) summary
    TIGR01661
    Location:62 → 387
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  20. XM_041566190.1 → XP_041422124.1  ELAV-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B7ZSI9, Q52KU1, Q91583, Q91903
    UniProtKB/TrEMBL
    A0A8J1L0R0
    Conserved Domains (1) summary
    TIGR01661
    Location:63 → 388
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  21. XM_041567000.1 → XP_041422934.1  ELAV-like protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A8J1L2Y9
    Conserved Domains (1) summary
    TIGR01661
    Location:1 → 225
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91903.2 GenPept UniProtKB/Swiss-Prot:Q91903

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