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gss.L glutathione synthetase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394329, updated on 4-Nov-2024

Summary

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Official Symbol
gss.L
Official Full Name
glutathione synthetase L homeolog
Primary source
Xenbase:XB-GENE-6254454
Locus tag
XELAEV_18043940mg
See related
EnsemblRapid:ENSXLAG00005030973 AllianceGenome:Xenbase:XB-GENE-6254454
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gss; gssls-a
Summary
Predicted to enable anion binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to act upstream of or within glutathione biosynthetic process. Predicted to be located in cytosol. Is expressed in liver and biliary system and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See gss.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (43590997..43606714, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (33274056..33289909, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121398204 Neighboring gene acyl-CoA synthetase short chain family member 2, gene 1 L homeolog Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta L homeolog Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of the large subunit of glutathione synthetase from Xenopus laevis embryos. Habenicht A, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 7916638
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione synthetase
Names
GSH synthetase
GSH-S
glutathione synthase
glutathione synthetase, large subunit
NP_001081013.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087544.1 → NP_001081013.1  glutathione synthetase

    See identical proteins and their annotated locations for NP_001081013.1

    Status: PROVISIONAL

    Source sequence(s)
    X69662
    UniProtKB/Swiss-Prot
    P35668
    UniProtKB/TrEMBL
    A0A974BXN4, Q6DCN4
    Related
    ENSXLAP00005093210.1, ENSXLAT00005094893.1
    Conserved Domains (1) summary
    cd00228
    Location:6 → 474
    eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    43590997..43606714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35668.1 GenPept UniProtKB/Swiss-Prot:P35668

Gene LinkOut

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