mre11.L MRE11 homolog, double strand break repair nuclease L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mre11.L
Official Full Name: MRE11 homolog, double strand break repair nuclease L homeolog
Primary source: Xenbase:XB-GENE-957959
Locus tag: XELAEV_18013860mg
See related: EnsemblRapid:ENSXLAG00005026089
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mre11; mre11a; mre11-a; mre11a.L
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Genomic context

Location:: chromosome: 2L

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (174965615..175064270)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (167647491..167746351)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRN complex is not required for efficient and accurate NHEJ-mediated repair of DSBs in this vertebrate system.
Title: Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.
suggests that Mre11-Rad50-Nbs1 inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.
Title: PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.
Brca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to genome instability.
Title: Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.
these findings suggest that the structure of ends is a major determinant for the pathway choice of DSB repair and the Mre11 nuclease dependency of resection.
Title: The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair.
MRN (Mre11, Rad50, and Nbs1) complex, CtIP, and BRCA1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducted DSB ends.
Title: MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts.
these data point to Mre11 as an important locus of Rsk-mediated checkpoint inhibition acting upstream of ATM activation.
Title: Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
The MRN complex, in particular the nuclease activity of Mre11, plays an important role in the activation of Chk1 in response to stalled replication forks.
Title: The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.
MRN (MRE11-RAD50-NBS1) complex has role in ATR activation via TOPBP1 recruitment.
Title: A role for the MRN complex in ATR activation via TOPBP1 recruitment.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
Title: RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks.
Results indicate a role for the X. laevis Mre11/Rad50/Nbs1 complex in microhomology-mediated end joining.
Title: The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA endodeoxyribonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA strand resection involved in replication fork processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within meiotic DNA double-strand break formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metaphase chromosome alignment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitochondrial double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within telomere maintenance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Mre11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Mre11 complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: double-strand break repair protein MRE11

Names: MRE11 homolog A, double strand break repair nuclease L homeolog; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; putative nuclease Mre11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087506.1 → NP_001080975.1 double-strand break repair protein MRE11

See identical proteins and their annotated locations for NP_001080975.1

Status: PROVISIONAL

Source sequence(s)

AF134569

UniProtKB/Swiss-Prot

Q2TAT5, Q9W6K1

Related

ENSXLAP00005078505.1, ENSXLAT00005080095.1

Conserved Domains (4) summary

TIGR00583
Location:11 → 403

mre11; DNA repair protein (mre11)

cd00840
Location:15 → 276

MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain

pfam04152
Location:296 → 464

Mre11_DNA_bind; Mre11 DNA-binding presumed domain

cl12013
Location:457 → 537

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature