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pafah1b1a platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a [ Danio rerio (zebrafish) ]

Gene ID: 394246, updated on 2-Nov-2024

Summary

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Official Symbol
pafah1b1aprovided by ZNC
Official Full Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040116-2
See related
Ensembl:ENSDARG00000032013 AllianceGenome:ZFIN:ZDB-GENE-040116-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable dynein complex binding activity; microtubule plus-end binding activity; and protein heterodimerization activity. Acts upstream of or within brain morphogenesis. Located in cytoplasm. Is expressed in several structures, including bone tissue; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pafah1b1a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (25272198..25319586, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (25336935..25384321, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene MAX network transcriptional repressor a Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene clustered mitochondria (cluA/CLU1) homolog a Neighboring gene coiled-coil domain containing 92Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the overlapping expression patterns of the zebrafish LIS1 orthologs. Drerup CM, et al. Gene Expr Patterns, 2010 Jan. PMID 19822223
  2. Expression and function on embryonic development of lissencephaly-1 genes in zebrafish. Sun C, et al. Acta Biochim Biophys Sin (Shanghai), 2009 Aug. PMID 19657569
  3. Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Tsujikawa M, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17785424, Free PMC Article
  4. Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Bercier V, et al. Mol Neurodegener, 2019 Jul 10. PMID 31291987, Free PMC Article
  5. Phenotypic analysis of catastrophic childhood epilepsy genes. Griffin A, et al. Commun Biol, 2021 Jun 3. PMID 34083748, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule sliding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reelin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lissencephaly-1 homolog A
Names
lis1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201345.1 → NP_958502.1  lissencephaly-1 homolog A

    See identical proteins and their annotated locations for NP_958502.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053205
    UniProtKB/Swiss-Prot
    Q07DR1, Q7T394
    UniProtKB/TrEMBL
    B2GQS8
    Related
    ENSDARP00000042217.5, ENSDART00000042218.6
    Conserved Domains (4) summary
    COG2319
    Location:100 → 410
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:9 → 35
    LisH; LisH
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    25272198..25319586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157575.5 → XP_005157632.1  lissencephaly-1 homolog A isoform X1

    See identical proteins and their annotated locations for XP_005157632.1

    UniProtKB/Swiss-Prot
    Q07DR1, Q7T394
    UniProtKB/TrEMBL
    B2GQS8
    Conserved Domains (4) summary
    COG2319
    Location:100 → 410
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08513
    Location:9 → 35
    LisH; LisH
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T394.3 GenPept UniProtKB/Swiss-Prot:Q7T394

Gene LinkOut

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