arpc1a actin related protein 2/3 complex, subunit 1A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arpc1aprovided by ZNC
Official Full Name: actin related protein 2/3 complex, subunit 1Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040116-1
See related: Ensembl:ENSDARG00000008383 AllianceGenome:ZFIN:ZDB-GENE-040116-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fk93e03
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of actin filament polymerization. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleus. Predicted to be part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (40796111..40804455)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (40654253..40662597)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201343.2 → NP_958500.1 actin-related protein 2/3 complex subunit 1A

See identical proteins and their annotated locations for NP_958500.1

Status: VALIDATED

Source sequence(s)

BX649559

UniProtKB/TrEMBL

B2GP38, Q7ZUQ0

Related

ENSDARP00000005640.3, ENSDART00000014729.6

Conserved Domains (3) summary

COG2319
Location:1 → 362

WD40; WD40 repeat [General function prediction only]

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl02567
Location:45 → 277

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...