bokb BCL2 family apoptosis regulator BOK b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bokbprovided by ZNC
Official Full Name: BCL2 family apoptosis regulator BOK bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1346
See related: Ensembl:ENSDARG00000008807 AllianceGenome:ZFIN:ZDB-GENE-040426-1346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: BOK; zBok2; zgc:64041
Summary: Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in extrinsic apoptotic signaling pathway in absence of ligand and intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including chordo neural hinge; nervous system; neural tube; ovary; and solid lens vesicle. Orthologous to human BOK (BCL2 family apoptosis regulator BOK). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (22640215..22650427)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (22984809..22994776)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-related ovarian killer protein homolog B

Names: BCL2-related ovarian killer b; BOK, BCL2 family apoptosis regulator b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201185.2 → NP_957479.2 bcl-2-related ovarian killer protein homolog B

Status: VALIDATED

Source sequence(s)

BX897733

UniProtKB/Swiss-Prot

Q0GKC3, Q7T381

UniProtKB/TrEMBL

B2GRX5

Related

ENSDARP00000123352.1, ENSDART00000144890.2