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rhoca ras homolog family member Ca [ Danio rerio (zebrafish) ]

Gene ID: 394125, updated on 19-Jun-2024

Summary

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Official Symbol
rhocaprovided by ZNC
Official Full Name
ras homolog family member Caprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1337
See related
Ensembl:ENSDARG00000021309 AllianceGenome:ZFIN:ZDB-GENE-040426-1337
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ARHC; rhoae; zgc:64015
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and neuron projection. Is expressed in hindbrain; notochord; and rhombomere. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See rhoca in Genome Data Viewer
Location:
chromosome: 6
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (48382697..48417939, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (48383938..48419180, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1a Neighboring gene Mov10 RNA helicase a Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1J Neighboring gene TAFA chemokine like family member 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. Hoeppner LH, et al. J Cell Sci, 2015 Oct 1. PMID 26136364, Free PMC Article
  2. m(6)A modulates haematopoietic stem and progenitor cell specification. Zhang C, et al. Nature, 2017 Sep 14. PMID 28869969
  3. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
  4. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
  5. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC64015

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle satellite cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras homolog family member Ca
Names
ras homolog gene family, member Ae

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201150.1 → NP_957444.1  ras homolog family member Ca

    See identical proteins and their annotated locations for NP_957444.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053200
    UniProtKB/TrEMBL
    A0A8M1PIV7, Q7T399
    Related
    ENSDARP00000084961.3, ENSDART00000090528.5
    Conserved Domains (2) summary
    smart00174
    Location:8 → 180
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    48382697..48417939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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