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INPP5E Inositol polyphosphate 5-phosphatase E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39404, updated on 22-Aug-2024

Summary

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Official Symbol
INPP5Eprovided by FlyBase
Official Full Name
Inositol polyphosphate 5-phosphatase Eprovided by FlyBase
Primary source
FLYBASE:FBgn0036273
Locus tag
Dmel_CG10426
See related
AllianceGenome:FB:FBgn0036273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10426; dInpp5e; Dmel\CG10426; Inpp5e; INPPE5; IPP
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in protein localization to cilium and sensory perception of sound. Located in ciliary base. Is expressed in several structures, including embryonic/larval nervous system; embryonic/larval salivary gland; endocrine system component; and eye disc. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See INPP5E in Genome Data Viewer
Location:
69A5-69A5; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12277655..12281476)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12270755..12274576)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase Neighboring gene Spermine synthase Neighboring gene long non-coding RNA:CR46241 Neighboring gene long non-coding RNA:CR45658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila. Park J, et al. Cell Rep, 2015 Dec 29. PMID 26723017
  2. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
  3. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Zirin J, et al. Proc Natl Acad Sci U S A, 2019 Jul 16. PMID 31262815, Free PMC Article
  4. Phosphoinositides and Cell Polarity in the Drosophila Egg Chamber. Jouette J, et al. Results Probl Cell Differ, 2017. PMID 28779318
  5. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inositol polyphosphate 5-phosphatase E
Names
CG10426-PA
CG10426-PB
INPP5E-PA
INPP5E-PB
pharbin-like
NP_001261753.1
NP_648566.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12277655..12281476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140309.2 → NP_648566.1  inositol polyphosphate 5-phosphatase E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648566.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTW2
    Related
    FBpp0075739
    Conserved Domains (1) summary
    cl00490
    Location:387 → 703
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001274824.1 → NP_001261753.1  inositol polyphosphate 5-phosphatase E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTW2
    Conserved Domains (1) summary
    cl00490
    Location:387 → 703
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTW2.1 Q9VTW2

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