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ddx41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 [ Danio rerio (zebrafish) ]

Gene ID: 394020, updated on 2-Nov-2024

Summary

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Official Symbol
ddx41provided by ZNC
Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1927
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-1927
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55896; wu:fb92e02
Summary
Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and zinc ion binding activity. Acts upstream of or within several processes, including nucleate erythrocyte development; positive regulation of non-canonical NF-kappaB signal transduction; and response to virus. Located in cytoplasm and nucleus. Is expressed in brain; digestive system; gill; heart; and immune system. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ddx41 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (49934289..49943269, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (44785743..44795035, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Neighboring gene ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like Neighboring gene family with sequence similarity 193 member B Neighboring gene abhydrolase domain containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Grouper DDX41 exerts antiviral activity against fish iridovirus and nodavirus infection. Liu J, et al. Fish Shellfish Immunol, 2019 Aug. PMID 31082519
  2. Molecular and functional characterization of tilapia DDX41 in IFN regulation. Gan Z, et al. Fish Shellfish Immunol, 2020 Apr. PMID 32081808
  3. Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish. Ge R, et al. J Virol, 2015 Aug. PMID 25972544, Free PMC Article
  4. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Weinreb JT, et al. Dev Cell, 2021 Mar 8. PMID 33651979, Free PMC Article
  5. Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish. Weinreb JT, et al. Haematologica, 2022 Mar 1. PMID 33763998, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
    Title: Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55896

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleate erythrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to virus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX41
XP_017214653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    49934289..49943269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017359164.3 → XP_017214653.1  probable ATP-dependent RNA helicase DDX41

    UniProtKB/TrEMBL
    A0A8M6Z9J0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201045.1: Suppressed sequence

    Description
    NM_201045.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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