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aacs acetoacetyl-CoA synthetase [ Danio rerio (zebrafish) ]

Gene ID: 393984, updated on 17-Aug-2024

Summary

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Official Symbol
aacsprovided by ZNC
Official Full Name
acetoacetyl-CoA synthetaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-903
See related
Ensembl:ENSDARG00000012468 AllianceGenome:ZFIN:ZDB-GENE-040426-903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56105
Summary
Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in liver; nervous system; neural tube; and optic vesicle. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See aacs in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (18822795..18897482, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (18319006..18393786, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-215k6.1 Neighboring gene uncharacterized LOC103911060 Neighboring gene bri3 binding protein Neighboring gene polymerase (DNA directed) iota

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate. Buerger AN, et al. Environ Pollut, 2019 Feb. PMID 30682743
  2. Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. Mirbahai L, et al. BMC Genomics, 2011 Jan 4. PMID 21205313, Free PMC Article
  3. Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Kopp R, et al. Physiol Genomics, 2010 Sep. PMID 20571107
  4. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC56105

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetoacetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetoacetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetoacetyl-CoA synthetase
NP_957303.1
XP_005165133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201009.1 → NP_957303.1  acetoacetyl-CoA synthetase

    See identical proteins and their annotated locations for NP_957303.1

    Status: PROVISIONAL

    Source sequence(s)
    BC050501
    UniProtKB/Swiss-Prot
    A3QK15
    Related
    ENSDARP00000090207.5, ENSDART00000099434.5
    Conserved Domains (2) summary
    cd05943
    Location:40 → 650
    AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
    TIGR01217
    Location:16 → 658
    ac_ac_CoA_syn; acetoacetyl-CoA synthase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    18822795..18897482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165076.4 → XP_005165133.1  acetoacetyl-CoA synthetase isoform X1

    See identical proteins and their annotated locations for XP_005165133.1

    UniProtKB/Swiss-Prot
    A3QK15, Q7ZU87
    Related
    ENSDARP00000002180.8, ENSDART00000010101.10
    Conserved Domains (2) summary
    cd05943
    Location:40 → 664
    AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)
    TIGR01217
    Location:16 → 672
    ac_ac_CoA_syn; acetoacetyl-CoA synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3QK15.1 GenPept UniProtKB/Swiss-Prot:A3QK15

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