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znf143b zinc finger protein 143b [ Danio rerio (zebrafish) ]

Gene ID: 393954, updated on 2-Nov-2024

Summary

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Official Symbol
znf143bprovided by ZNC
Official Full Name
zinc finger protein 143bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1586
See related
Ensembl:ENSDARG00000041581 AllianceGenome:ZFIN:ZDB-GENE-040426-1586
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Zfp143; znf143; zgc:66276
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in forebrain; hindbrain; and midbrain. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See znf143b in Genome Data Viewer
Location:
chromosome: 18
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16924873..16937110, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (16935614..16948060, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene switching B cell complex subunit SWAP70b Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene si:dkey-8l13.5 Neighboring gene si:ch211-242e8.1 Neighboring gene A kinase (PRKA) interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development. Huning L, et al. BMC Mol Cell Biol, 2020 Jan 22. PMID 31969120, Free PMC Article
  2. CHD8short, a naturally-occurring truncated form of a chromatin remodeler lacking the helicase domain, is a potent transcriptional coregulator. Kunkel GR, et al. Gene, 2018 Jan 30. PMID 29079199
  3. Characterization of snRNA and snRNA-type genes in the pufferfish Fugu rubripes. Myslinski E, et al. Gene, 2004 Apr 14. PMID 15087134
  4. The transcriptional activator ZNF143 is essential for normal development in zebrafish. Halbig KM, et al. BMC Mol Biol, 2012 Jan 23. PMID 22268977, Free PMC Article
  5. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Benner MJ, et al. Physiol Genomics, 2013 Aug 1. PMID 23737534, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development.
    Title: Two paralogous znf143 genes in zebrafish encode transcriptional activator proteins with similar functions but expressed at different levels during early development.
  2. The knockdown of the transcriptional activator ZNF143 by injection of translational-blocking Morpholino Oligonucleotides causes many significant phenotypic effects in zebrafish embryos
    Title: The transcriptional activator ZNF143 is essential for normal development in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC66276

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 143
Names
selenocysteine tRNA activating factor
selenocysteine tRNA gene transcription-activating factor
staf
NP_957273.1
XP_005159129.1
XP_005159130.1
XP_009291820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200979.1 → NP_957273.1  zinc finger protein 143

    See identical proteins and their annotated locations for NP_957273.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055577
    UniProtKB/TrEMBL
    Q7SXJ2
    Related
    ENSDARP00000090890.3, ENSDART00000100117.3
    Conserved Domains (4) summary
    COG5048
    Location:166 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:253 → 280
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:269 → 349
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    16924873..16937110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159073.5 → XP_005159130.1  zinc finger protein 143 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5J5
    Conserved Domains (3) summary
    sd00017
    Location:228 → 250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:302 → 329
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:318 → 398
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_005159072.5 → XP_005159129.1  zinc finger protein 143 isoform X1

    See identical proteins and their annotated locations for XP_005159129.1

    UniProtKB/Swiss-Prot
    A0AUQ7, Q1LYE3, Q6VQB1
    Related
    ENSDARP00000122626.1, ENSDART00000136541.3
    Conserved Domains (3) summary
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:306 → 333
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:322 → 402
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_009293545.4 → XP_009291820.1  zinc finger protein 143 isoform X1

    See identical proteins and their annotated locations for XP_009291820.1

    UniProtKB/Swiss-Prot
    A0AUQ7, Q1LYE3, Q6VQB1
    Related
    ENSDARP00000009795.8, ENSDART00000022640.10
    Conserved Domains (3) summary
    sd00017
    Location:232 → 254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:306 → 333
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:322 → 402
    zf-C2H2_8; C2H2-type zinc ribbon

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395017.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    629645..641882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    137960..149139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1LYE3.2 GenPept UniProtKB/Swiss-Prot:Q1LYE3

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