rab5ab RAB5A, member RAS oncogene family, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rab5abprovided by ZNC
Official Full Name: RAB5A, member RAS oncogene family, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040122-3
See related: Ensembl:ENSDARG00000007257 AllianceGenome:ZFIN:ZDB-GENE-040122-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Rab5a; rab5al; zgc:56644
Summary: Predicted to enable GTPase activity. Acts upstream of or within several processes, including Spemann organizer formation; epiboly involved in gastrulation with mouth forming second; and nodal signaling pathway. Predicted to be located in early endosome membrane and plasma membrane. Predicted to be active in axon and postsynaptic early endosome. Orthologous to human RAB5A (RAB5A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (49647436..49661406)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (49423443..49437413)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rab5ab is essential for nodal signalling and organizer specification in the developing zebrafish embryo.
Title: Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nodal signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RAB5A, member RAS oncogene family, b

Names: RAB5A, member RAS oncogene family like

NP_957264.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200970.1 → NP_957264.1 RAB5A, member RAS oncogene family, b

See identical proteins and their annotated locations for NP_957264.1

Status: PROVISIONAL

Source sequence(s)

BC049057

UniProtKB/TrEMBL

A0A8M1PDS5, Q7ZUG4

Related

ENSDARP00000010427.5, ENSDART00000015694.7

Conserved Domains (2) summary

cd01860
Location:21 → 183

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

pfam00071
Location:23 → 184

Ras; Ras family