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rad1 RAD1 homolog (S. pombe) [ Danio rerio (zebrafish) ]

Gene ID: 393872, updated on 25-Apr-2024

Summary

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Official Symbol
rad1provided by ZNC
Official Full Name
RAD1 homolog (S. pombe)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1873
See related
Ensembl:ENSDARG00000040559 AllianceGenome:ZFIN:ZDB-GENE-040426-1873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56502; zgc:77779
Summary
Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rad1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23780499..23784518, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23845234..23849253, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene BCL2 binding component 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) Neighboring gene transmembrane protein 97 Neighboring gene si:ch211-167j9.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77779

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell cycle checkpoint protein RAD1
NP_957192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200898.1 → NP_957192.1  cell cycle checkpoint protein RAD1

    See identical proteins and their annotated locations for NP_957192.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064305
    UniProtKB/TrEMBL
    A0A8M1PI65, Q6P2T4
    Related
    ENSDARP00000059353.5, ENSDART00000059354.6
    Conserved Domains (2) summary
    cd00577
    Location:18 → 275
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:15 → 256
    Rad1; Repair protein Rad1/Rec1/Rad17

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    23780499..23784518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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