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guk1b guanylate kinase 1b [ Danio rerio (zebrafish) ]

Gene ID: 393697, updated on 2-Nov-2024

Summary

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Official Symbol
guk1bprovided by ZNC
Official Full Name
guanylate kinase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020916-1
See related
Ensembl:ENSDARG00000005776 AllianceGenome:ZFIN:ZDB-GENE-020916-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
guk1; zgc:73128; zgc:73217
Summary
Predicted to enable guanylate kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in epiphysis; retina; retinal outer nuclear layer; and retinal photoreceptor layer. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See guk1b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18230948..18340144, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18195248..18203815, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 8b Neighboring gene mutY DNA glycosylase Neighboring gene ring finger protein 220b Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutant Prpf31 causes pre-mRNA splicing defects and rod photoreceptor cell degeneration in a zebrafish model for Retinitis pigmentosa. Yin J, et al. Mol Neurodegener, 2011 Jul 30. PMID 21801444, Free PMC Article
  2. Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: ocular developmental toxicity. Huang L, et al. Chemosphere, 2014 Aug. PMID 24875912
  3. Cellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas. Hensley MR, et al. BMC Dev Biol, 2011 Jul 14. PMID 21756345, Free PMC Article
  4. Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. Ben-Moshe Livne Z, et al. PLoS Genet, 2016 Nov. PMID 27870848, Free PMC Article
  5. Gene expression profiling of zebrafish embryonic retina. Leung YF, et al. Zebrafish, 2005. PMID 18248185

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC73128

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanylate kinase 1b
Names
guanylate kinase 1
NP_957018.1
XP_005166853.1
XP_068079002.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200724.1 → NP_957018.1  guanylate kinase 1b

    See identical proteins and their annotated locations for NP_957018.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059491
    UniProtKB/TrEMBL
    Q6PC32
    Related
    ENSDARP00000023640.7, ENSDART00000022959.9
    Conserved Domains (2) summary
    TIGR03263
    Location:5 → 213
    guanyl_kin; guanylate kinase
    COG0194
    Location:1 → 219
    Gmk; Guanylate kinase [Nucleotide transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    18230948..18340144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222901.1 → XP_068079002.1  guanylate kinase 1b isoform X1

  2. XM_005166796.4 → XP_005166853.1  guanylate kinase 1b isoform X2

    UniProtKB/TrEMBL
    A0A8M2BEA8, B8JJJ6
    Related
    ENSDARP00000074439.5, ENSDART00000079989.7
    Conserved Domains (2) summary
    TIGR03263
    Location:5 → 187
    guanyl_kin; guanylate kinase
    pfam00625
    Location:3 → 188
    Guanylate_kin; Guanylate kinase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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