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nat10 N-acetyltransferase 10 [ Danio rerio (zebrafish) ]

Gene ID: 393617, updated on 2-Nov-2024

Summary

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Official Symbol
nat10provided by ZNC
Official Full Name
N-acetyltransferase 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1543
See related
Ensembl:ENSDARG00000054259 AllianceGenome:ZFIN:ZDB-GENE-040426-1543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66119
Summary
Predicted to enable rRNA cytidine N-acetyltransferase activity and tRNA binding activity. Predicted to be involved in rRNA acetylation involved in maturation of SSU-rRNA. Predicted to act upstream of or within rRNA processing and tRNA processing. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; immature eye; nervous system; neural plate; and segmental plate. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See nat10 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (38216816..38244869, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (38235808..38263861, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene leucine zipper protein 2 Neighboring gene si:dkey-10o6.2 Neighboring gene nucleobindin 2b Neighboring gene cell cycle associated protein 1b Neighboring gene uncharacterized LOC137488324

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Yang HZ, et al. Invest Ophthalmol Vis Sci, 2024 Feb 1. PMID 38381411, Free PMC Article
  2. Pbx homeodomain proteins pattern both the zebrafish retina and tectum. French CR, et al. BMC Dev Biol, 2007 Jul 16. PMID 17634100, Free PMC Article
  3. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Fellous A, et al. Gene, 2019 Apr 5. PMID 30615915
  4. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function.
    Title: Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC66119

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA cytidine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA acetylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA cytidine acetyltransferase
NP_956938.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200644.1 → NP_956938.1  RNA cytidine acetyltransferase

    See identical proteins and their annotated locations for NP_956938.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057462
    UniProtKB/TrEMBL
    Q6PFQ5
    Related
    ENSDARP00000070873.4, ENSDART00000076399.5
    Conserved Domains (5) summary
    COG1444
    Location:24 → 908
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
    pfam05127
    Location:283 → 482
    Helicase_RecD; Helicase
    pfam08351
    Location:109 → 203
    DUF1726; Domain of unknown function (DUF1726)
    pfam13718
    Location:530 → 754
    GNAT_acetyltr_2; GNAT acetyltransferase 2
    pfam13725
    Location:777 → 894
    tRNA_bind_2; Possible tRNA binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    38216816..38244869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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