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slc5a12 solute carrier family 5 member 12 [ Danio rerio (zebrafish) ]

Gene ID: 393339, updated on 12-Sep-2024

Summary

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Official Symbol
slc5a12provided by ZNC
Official Full Name
solute carrier family 5 member 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1343
See related
Ensembl:ENSDARG00000005004 AllianceGenome:ZFIN:ZDB-GENE-040426-1343
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
smctn; zgc:64037
Summary
Enables secondary active monocarboxylate transmembrane transporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in gut; immature eye; nervous system; neurocranial trabecula; and pleuroperitoneal region. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See slc5a12 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (35474987..35527499, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (34966516..35019238, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene small VCP interacting protein Neighboring gene anoctamin 3 Neighboring gene fin bud initiation factor a Neighboring gene transmembrane protein 276a Neighboring gene Spi-1 proto-oncogene a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8). Plata C, et al. J Biol Chem, 2007 Apr 20. PMID 17255103
  2. Insulin and SGK1 reduce the function of Na+/monocarboxylate transporter 1 (SMCT1/SLC5A8). López-Barradas A, et al. Am J Physiol Cell Physiol, 2016 Nov 1. PMID 27488665, Free PMC Article
  3. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. zSMCTe is the zebrafish SLC5A8 ortholog, and zSMCTn is a novel, electroneutral SMCT (zSlc5a12)
    Title: Zebrafish Slc5a12 encodes an electroneutral sodium monocarboxylate transporter (SMCTn). A comparison with the electrogenic SMCT (SMCTe/Slc5a8).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC64037

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monocarboxylate:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secondary active monocarboxylate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium-coupled monocarboxylate transporter 2
Names
electroneutral sodium monocarboxylate cotransporter
low-affinity sodium-lactate cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
zSLC5A12
zSMCTn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200368.1 → NP_956662.1  sodium-coupled monocarboxylate transporter 2

    See identical proteins and their annotated locations for NP_956662.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053215
    UniProtKB/Swiss-Prot
    Q7T384
    Related
    ENSDARP00000013866.9, ENSDART00000009271.9
    Conserved Domains (1) summary
    cd11520
    Location:4 → 533
    SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    35474987..35527499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068217337.1 → XP_068073438.1  sodium-coupled monocarboxylate transporter 2 isoform X1

    Related
    ENSDARP00000128187.1, ENSDART00000156782.3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7T384.1 GenPept UniProtKB/Swiss-Prot:Q7T384

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.