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st3gal3a ST3 beta-galactoside alpha-2,3-sialyltransferase 3a [ Danio rerio (zebrafish) ]

Gene ID: 393326, updated on 2-Nov-2024

Summary

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Official Symbol
st3gal3aprovided by ZNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1322
See related
Ensembl:ENSDARG00000015374 AllianceGenome:ZFIN:ZDB-GENE-040426-1322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siat6; st3gal3; st3ga3-r; zgc:63978
Summary
Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including cardiovascular system; integument; liver; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 12 and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See st3gal3a in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3334378..3405497)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (3174069..3245200)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type Fa Neighboring gene lysine (K)-specific demethylase 4A, genome duplicate a Neighboring gene uncharacterized LOC108190362 Neighboring gene artemin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  2. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
  3. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC63978

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
Names
SIAT6-r
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
st3gal3-r2
NP_956649.2
XP_021332477.1
XP_021332479.1
XP_021332480.1
XP_021332481.1
XP_068077772.1
XP_068077773.1
XP_068077774.1
XP_068077775.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200355.2 → NP_956649.2  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a

    Status: VALIDATED

    Source sequence(s)
    BX119315
    Related
    ENSDARP00000107939.2, ENSDART00000130879.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    3334378..3405497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476802.2 → XP_021332477.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLX6, Q7T3B9
    Conserved Domains (1) summary
    pfam00777
    Location:107 → 398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_021476805.2 → XP_021332480.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M9QF92, Q7T3B9
    Conserved Domains (1) summary
    pfam00777
    Location:91 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_068221671.1 → XP_068077772.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X3

  4. XM_021476806.2 → XP_021332481.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M9QF92, Q7T3B9
    Conserved Domains (1) summary
    pfam00777
    Location:91 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_068221672.1 → XP_068077773.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X3

  6. XM_021476804.2 → XP_021332479.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PLX6, Q7T3B9
    Conserved Domains (1) summary
    pfam00777
    Location:107 → 398
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_068221674.1 → XP_068077775.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X4

  8. XM_068221673.1 → XP_068077774.1  ST3 beta-galactoside alpha-2,3-sialyltransferase 3a isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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