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gbgt1l1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1 [ Danio rerio (zebrafish) ]

Gene ID: 393300, updated on 2-Nov-2024

Summary

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Official Symbol
gbgt1l1provided by ZNC
Official Full Name
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1117
See related
Ensembl:ENSDARG00000025275 AllianceGenome:ZFIN:ZDB-GENE-040426-1117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56701
Summary
Predicted to enable glycosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to several human genes including GBGT1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See gbgt1l1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23702012..23715874, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23198495..23212015, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8B Neighboring gene ring finger protein 128a Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals--a birth-and-death evolution model. Turcot-Dubois AL, et al. Glycobiology, 2007 May. PMID 17298992
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC56701

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1
Names
FS-L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200329.1 → NP_956623.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1

    See identical proteins and their annotated locations for NP_956623.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052142
    UniProtKB/TrEMBL
    Q7ZTV7
    Related
    ENSDARP00000018900.5, ENSDART00000019992.7
    Conserved Domains (1) summary
    cd02515
    Location:43 → 313
    Glyco_transf_6; Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    23702012..23715874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221121.1 → XP_068077222.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1 isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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