usp44 ubiquitin specific peptidase 44 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: usp44provided by ZNC
Official Full Name: ubiquitin specific peptidase 44provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-774
See related: Ensembl:ENSDARG00000089861 AllianceGenome:ZFIN:ZDB-GENE-040426-774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55661
Summary: Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (26021746..26035770, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (26032548..26046572, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 44

Names: deubiquitinating enzyme 44; ubiquitin thioesterase 44; ubiquitin thiolesterase 44; ubiquitin-specific-processing protease 44

NP_956551.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200257.1 → NP_956551.1 ubiquitin carboxyl-terminal hydrolase 44

See identical proteins and their annotated locations for NP_956551.1

Status: PROVISIONAL

Source sequence(s)

BC048060

UniProtKB/Swiss-Prot

Q7ZUM8

UniProtKB/TrEMBL

B2GNP5

Related

ENSDARP00000104741.1, ENSDART00000124514.3

Conserved Domains (4) summary

cl02553
Location:296 → 682

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:294 → 681

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:26 → 88

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

pfam07432
Location:204 → 274

Hc1; Histone H1-like protein Hc1