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crim crimpled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39321, updated on 18-Sep-2024

Summary

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Official Symbol
crimprovided by FlyBase
Official Full Name
crimpledprovided by FlyBase
Primary source
FLYBASE:FBgn0036198
Locus tag
Dmel_CG6038
See related
AllianceGenome:FB:FBgn0036198
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6038; Crim; Dmel\CG6038
Summary
Involved in liquid clearance, open tracheal system; regulation of tube size, open tracheal system; and septate junction assembly. Located in septate junction. Is expressed in several structures, including adult head; early extended germ band embryo; embryonic dorsal epidermis; foregut primordium; and presumptive embryonic/larval digestive system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See crim in Genome Data Viewer
Location:
68D2-68D3; 3-36 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11710507..11711386, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11703607..11704486, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene uncharacterized protein Neighboring gene bmcp

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
  2. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. Oshima K, et al. J Cell Sci, 2011 Aug 15. PMID 21807950, Free PMC Article
  3. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
  4. The Drosophila septate junctions beyond barrier function: Review of the literature, prediction of human orthologs of the SJ-related proteins and identification of protein domain families. Rouka E, et al. Acta Physiol (Oxf), 2021 Jan. PMID 32603029
  5. Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components. Nilton A, et al. Development, 2010 Jul. PMID 20570942, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
crimpled
Names
CG6038-PA
crim-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11710507..11711386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140243.4 → NP_648500.1  crimpled [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648500.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTM6
    Related
    FBpp0075854
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTM6 Q9VTM6
Q9VTM6.1

Gene LinkOut

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