sh3gl3b SH3-domain GRB2-like 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sh3gl3bprovided by ZNC
Official Full Name: SH3-domain GRB2-like 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040121-4
See related: Ensembl:ENSDARG00000007302 AllianceGenome:ZFIN:ZDB-GENE-040121-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sh3gl3; zgc:55890
Summary: Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in blood island; notochord; posterior lateral mesoderm; and vasculature. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (19522997..19536001)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (19424806..19438289)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel lumenization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel lumenization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle uncoating	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: endophilin-A3b

Names: SH3-domain GRB2-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200181.2 → NP_956475.2 endophilin-A3b

See identical proteins and their annotated locations for NP_956475.2

Status: PROVISIONAL

Source sequence(s)

AY398419

UniProtKB/TrEMBL

A0A8M1PE57, Q6TGT7

Related

ENSDARP00000007836.5, ENSDART00000006512.7

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:327 → 381

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

19522997..19536001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163002.5 → XP_005163059.1 endophilin-A3b isoform X1

UniProtKB/TrEMBL

A0A2R8QD99, A0A8M2B9Z0

Related

ENSDARP00000151600.1, ENSDART00000184279.1

Conserved Domains (2) summary

cd07592
Location:25 → 247

BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A

cd11803
Location:316 → 370

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
XM_068217336.1 → XP_068073437.1 endophilin-A3b isoform X2
XM_009297893.4 → XP_009296168.1 endophilin-A3b isoform X2

UniProtKB/TrEMBL

A0A8M3AWG7

Conserved Domains (2) summary

cd11803
Location:258 → 312

SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature