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garem GRB2 associated, regulator of MAPK1 [ Danio rerio (zebrafish) ]

Gene ID: 393138, updated on 2-Nov-2024

Summary

Official Symbol
garemprovided by ZNC
Official Full Name
GRB2 associated, regulator of MAPK1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-767
See related
Ensembl:ENSDARG00000017242 AllianceGenome:ZFIN:ZDB-GENE-040426-767
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam59a; garem1; zgc:55634
Summary
Predicted to enable proline-rich region binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within positive regulation of cell division. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See garem in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (41340696..41348574)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (41060623..41068501)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 2 Neighboring gene neutrophil cytosolic factor 2 Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene uncharacterized LOC137496192

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC55634

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables proline-rich region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proline-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
GRB2-associated and regulator of MAPK protein 1
Names
GRB2-associated and regulator of MAPK1
family with sequence similarity 59, member A
protein FAM59A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200169.2NP_956463.1  GRB2-associated and regulator of MAPK protein 1

    See identical proteins and their annotated locations for NP_956463.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045411
    UniProtKB/Swiss-Prot
    Q7ZVU1
    Related
    ENSDARP00000024393.7, ENSDART00000005127.10
    Conserved Domains (2) summary
    cd09525
    Location:799865
    SAM_GAREM; SAM domain of GAREM subfamily
    pfam12736
    Location:32325
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    41340696..41348574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)