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manba mannosidase, beta A, lysosomal [ Danio rerio (zebrafish) ]

Gene ID: 393128, updated on 2-Nov-2024

Summary

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Official Symbol
manbaprovided by ZNC
Official Full Name
mannosidase, beta A, lysosomalprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-721
See related
Ensembl:ENSDARG00000008238 AllianceGenome:ZFIN:ZDB-GENE-040426-721
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55493; zgc:76896
Summary
Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See manba in Genome Data Viewer
Location:
chromosome: 13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (11719703..11744098, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (11587228..11611623, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 Neighboring gene solute carrier family 39 member 8 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene zmp:0000000662

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease. Ko YA, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575649, Free PMC Article
  2. Proteome Profile of Myelin in the Zebrafish Brain. Siems SB, et al. Front Cell Dev Biol, 2021. PMID 33898427, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55493

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-mannosidase
NP_956453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200159.1 → NP_956453.1  beta-mannosidase precursor

    See identical proteins and their annotated locations for NP_956453.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045360
    UniProtKB/TrEMBL
    Q7ZVY7
    Related
    ENSDARP00000073766.5, ENSDART00000079310.8
    Conserved Domains (4) summary
    COG3250
    Location:38 → 858
    LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
    pfam00703
    Location:237 → 343
    Glyco_hydro_2; Glycosyl hydrolases family 2
    pfam02837
    Location:94 → 163
    Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    cl23725
    Location:362 → 508
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    11719703..11744098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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