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Plod procollagen lysyl hydroxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39265, updated on 2-Nov-2024

Summary

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Official Symbol
Plodprovided by FlyBase
Official Full Name
procollagen lysyl hydroxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0036147
Locus tag
Dmel_CG6199
See related
AllianceGenome:FB:FBgn0036147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:ParkEST325; anon-WO0118547.416; CG6199; Dmel\CG6199; dplod; dPlod; LH3; plod; RE-H
Summary
Enables procollagen galactosyltransferase activity and procollagen glucosyltransferase activity. Involved in growth of a germarium-derived egg chamber. Located in endoplasmic reticulum; extracellular space; and perinuclear region of cytoplasm. Is expressed in several structures, including adult head; embryonic/larval anal pad; embryonic/larval hemocyte; nurse cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 1. Orthologous to several human genes including PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Plod in Genome Data Viewer
Location:
68B1-68B1; 3-35 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11198166..11206016, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11191266..11199116, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glucuronyltransferase P Neighboring gene uncharacterized protein Neighboring gene noktochor Neighboring gene Ubiquitin protein ligase E3A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster. Jha AR, et al. Mol Biol Evol, 2015 Oct. PMID 26044351, Free PMC Article
  2. A Secreted Ig-Domain Protein Required in Both Astrocytes and Neurons for Regulation of Drosophila Night Sleep. Sengupta S, et al. Curr Biol, 2019 Aug 5. PMID 31353186, Free PMC Article
  3. The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV. Peng Q, et al. J Genet Genomics, 2022 Jul. PMID 35017121
  4. Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod. Bunt S, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20888931, Free PMC Article
  5. Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Wilmes AC, et al. Biol Open, 2018 Apr 23. PMID 29685999, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables procollagen galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables procollagen glucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables procollagen-lysine 5-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables procollagen-lysine 5-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in growth of a germarium-derived egg chamber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
procollagen lysyl hydroxylase
Names
CG6199-PA
CG6199-PB
Plod-PA
Plod-PB
drosophila plod
lysyl hydroxylase
NP_648451.1
NP_729687.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11198166..11206016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168452.2 → NP_729687.1  procollagen lysyl hydroxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NR6, Q8MSV4, Q9VTH0
    Related
    FBpp0075918
    Conserved Domains (2) summary
    smart00702
    Location:555 → 719
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    cl11394
    Location:303 → 395
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. NM_140194.2 → NP_648451.1  procollagen lysyl hydroxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648451.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NR6, Q8MSV4, Q9VTH0
    Related
    FBpp0075917
    Conserved Domains (2) summary
    smart00702
    Location:555 → 719
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    cl11394
    Location:303 → 395
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTH0.1 Q9VTH0

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