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STMN1 stathmin 1 [ Homo sapiens (human) ]

Gene ID: 3925, updated on 7-Apr-2024

Summary

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Official Symbol
STMN1provided by HGNC
Official Full Name
stathmin 1provided by HGNC
Primary source
HGNC:HGNC:6510
See related
Ensembl:ENSG00000117632 MIM:151442; AllianceGenome:HGNC:6510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
Summary
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Expression
Broad expression in brain (RPKM 118.2), testis (RPKM 64.4) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25884179..25906880, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25721609..25744310, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26210670..26233371, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene progestin and adipoQ receptor family member 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:26216402-26217601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26217613-26218116 Neighboring gene Sharpr-MPRA regulatory region 13744 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 5934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 469 Neighboring gene uncharacterized LOC105376885 Neighboring gene microRNA 3917 Neighboring gene CRISPRi-validated cis-regulatory element chr1.3691 Neighboring gene RNA, U6 small nuclear 110, pseudogene Neighboring gene platelet activating factor acetylhydrolase 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:26320062-26320573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 474 Neighboring gene small Cajal body-specific RNA 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation. Zhang ED, et al. World J Surg Oncol, 2022 Sep 20. PMID 36127700, Free PMC Article
  2. Association of Stathmin (Op18) with TNM Staging and Grading of Oral Squamous Cell Carcinoma and Its Role in Tumor Progression. Vadla P, et al. J Contemp Dent Pract, 2022 May 1. PMID 35986456
  3. Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma. Cai Y, et al. Cell Death Dis, 2022 Feb 24. PMID 35210426, Free PMC Article
  4. Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer. Nie L, et al. Dis Markers, 2022. PMID 35186166, Free PMC Article
  5. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells. Vicari HP, et al. Invest New Drugs, 2022 Apr. PMID 34837603

See all (326) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma.
    Title: The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma.
  2. STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
    Title: STMN1 promotes cell malignancy and bortezomib resistance of multiple myeloma cell lines via PI3K/AKT signaling.
  3. Association Between High Expression of Phosphorylated-STMN1 and Mesenchymal Marker Expression and Cancer Stemness in Breast Cancer.
    Title: Association Between High Expression of Phosphorylated-STMN1 and Mesenchymal Marker Expression and Cancer Stemness in Breast Cancer.
  4. Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.
    Title: Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.
  5. Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.
    Title: Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions.
  6. STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.
    Title: STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.
  7. Association of Stathmin (Op18) with TNM Staging and Grading of Oral Squamous Cell Carcinoma and Its Role in Tumor Progression.
    Title: Association of Stathmin (Op18) with TNM Staging and Grading of Oral Squamous Cell Carcinoma and Its Role in Tumor Progression.
  8. STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
    Title: STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
  9. Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma.
    Title: Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma.
  10. Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer.
    Title: Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (222)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies STMN1, a factor involved in microtubule organization, as IN-binding partner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32206, MGC138869, MGC138870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tubulin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hepatocyte growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of thrombin-activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stathmin
Names
leukemia-associated phosphoprotein p18
metablastin
oncoprotein 18
phosphoprotein 19
phosphoprotein p19
prosolin
stathmin 1/oncoprotein 18
testicular tissue protein Li 189
transmembrane protein C1orf215

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145454.3 → NP_001138926.1  stathmin isoform b

    See identical proteins and their annotated locations for NP_001138926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript, and encodes the longer isoform (b).
    Source sequence(s)
    AK303692, AL033528, BC028398, BG493669
    Consensus CDS
    CCDS44090.1
    UniProtKB/TrEMBL
    A0A140VJW2
    Related
    ENSP00000410452.2, ENST00000426559.6
    Conserved Domains (1) summary
    pfam00836
    Location:9 → 126
    Stathmin; Stathmin family

  2. NM_005563.4 → NP_005554.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_005554.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, BG030679, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
    UniProtKB/TrEMBL
    B5BU83
    Related
    ENSP00000387858.2, ENST00000455785.7
    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

  3. NM_203399.2 → NP_981944.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_981944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, AL033528, BG030679, BM563894, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
    UniProtKB/TrEMBL
    B5BU83
    Related
    ENSP00000350531.2, ENST00000357865.6
    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

  4. NM_203401.2 → NP_981946.1  stathmin isoform a

    See identical proteins and their annotated locations for NP_981946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate terminal exon, compared to variant 4. The resulting isoform (a) has a shorter and distinct C-terminus, compared to isoform b. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK054594, BG030679, BQ428400, BQ772197
    Consensus CDS
    CCDS269.1
    UniProtKB/Swiss-Prot
    A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, P16949
    UniProtKB/TrEMBL
    B5BU83
    Related
    ENSP00000382633.1, ENST00000399728.5
    Conserved Domains (1) summary
    pfam00836
    Location:5 → 140
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25884179..25906880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25721609..25744310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152497.1: Suppressed sequence

    Description
    NM_152497.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16949.3 GenPept UniProtKB/Swiss-Prot:P16949

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
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