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TRIM61 tripartite motif containing 61 [ Homo sapiens (human) ]

Gene ID: 391712, updated on 3-Apr-2024

Summary

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Official Symbol
TRIM61provided by HGNC
Official Full Name
tripartite motif containing 61provided by HGNC
Primary source
HGNC:HGNC:24339
See related
Ensembl:ENSG00000183439 MIM:619417; AllianceGenome:HGNC:24339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF35
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.2), thyroid (RPKM 2.0) and 17 other tissues See more
Orthologs
all
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Genomic context

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See TRIM61 in Genome Data Viewer
Location:
4q32.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (164954446..164977657, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (168302109..168325338, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165875598..165898809, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NACA family member 3, pseudogene Neighboring gene tripartite motif-containing protein 60-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22112 Neighboring gene family with sequence similarity 218 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:165912150-165912843 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:165916505-165917374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165917390-165918172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:165918173-165918953 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:165922487-165923241 Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene ribosomal protein L21 pseudogene 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. Huang CJ, et al. J Biol Chem, 2005 Sep 2. PMID 15994318
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ60274, MGC102996

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative tripartite motif-containing protein 61
Names
ring finger protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012414.3 → NP_001012414.1  putative tripartite motif-containing protein 61 isoform 2

    See identical proteins and their annotated locations for NP_001012414.1

    Status: VALIDATED

    Source sequence(s)
    BC089393, CN311322
    Consensus CDS
    CCDS34093.1
    UniProtKB/Swiss-Prot
    Q5EBN2
    Related
    ENSP00000332288.5, ENST00000329314.6
    Conserved Domains (1) summary
    cd16607
    Location:13 → 59
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins

  2. NM_001414904.1 → NP_001401833.1  putative tripartite motif-containing protein 61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106872
    UniProtKB/TrEMBL
    A0A494C0U7
    Related
    ENSP00000518164.1, ENST00000710271.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    164954446..164977657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    168302109..168325338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349976.1 → XP_054205951.1  putative tripartite motif-containing protein 61 isoform X1

    UniProtKB/TrEMBL
    A0A494C0U7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5EBN2.1 GenPept UniProtKB/Swiss-Prot:Q5EBN2

Gene LinkOut

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