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USP17L9P ubiquitin specific peptidase 17 like family member 9, pseudogene [ Homo sapiens (human) ]

Gene ID: 391627, updated on 17-Sep-2024

Summary

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Official Symbol
USP17L9Pprovided by HGNC
Official Full Name
ubiquitin specific peptidase 17 like family member 9, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:12615
See related
Ensembl:ENSG00000251694 MIM:607011; AllianceGenome:HGNC:12615
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RS447; USP17; USP17A; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M
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Genomic context

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See USP17L9P in Genome Data Viewer
Location:
4p16.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9358382..9359974)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9378904..9380496)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9360108..9361700)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 17 like family member 28 Neighboring gene ubiquitin specific peptidase 17 like family member 29 Neighboring gene ubiquitin specific peptidase 17 like family member 30 Neighboring gene ubiquitin specific peptidase 17 like family member 6, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization. Kogi M, et al. Genomics, 1997 Jun 1. PMID 9192848
  2. The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis. McFarlane C, et al. Oncotarget, 2013 Oct. PMID 24123619, Free PMC Article
  3. Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells. Zhang S, et al. Oncol Res, 2016. PMID 27656837, Free PMC Article
  4. Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme. Hjortland NM, et al. Arch Biochem Biophys, 2016 Dec 15. PMID 27756680, Free PMC Article
  5. The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis. Nagasaka M, et al. FEBS Lett, 2022 Feb. PMID 35076962

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP17 regulates preeclampsia by modulating the NF-kappaB signaling pathway via deubiquitinating HDAC2.
    Title: USP17 regulates preeclampsia by modulating the NF-κB signaling pathway via deubiquitinating HDAC2.
  2. The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
    Title: The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
  3. Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRbeta and affect PDGF-BB-induced STAT3 signalling.
    Title: Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling.
  4. Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
    Title: Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
  5. our results show that ubiquitination of ELK-1 at K35, and its reversal by USP17, are important mechanisms in the regulation of nuclear ERK signalling and cellular proliferation. Our findings will be relevant for tumours that exhibit elevated USP17 expression and suggest a new target for intervention.
    Title: De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation.
  6. USP17L9P expression is significantly increased in healthy palatal mucosa of smokers
    Title: Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
  7. USP17 facilitates trafficking and oncogenic signaling of mutant EGFR
    Title: USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.
  8. MAD4 has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.
    Title: USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis, and epithelial-mesenchymal transition through stabilizing SMAD4.
  9. Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme
    Title: Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
  10. USP17 knockdown significantly suppressed the tumorigenesis ability of both the NSCLC cell lines A549 and H1299. Moreover, USP17 participated in the invasion of NSCLC cells. These functions of USP17 are partially mediated by regulating the expression of MMP proteins MMP3 and MMP9.
    Title: Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • deubiquitinating enzyme 17
  • ubiquitin carboxyl-terminal hydrolase 17
  • ubiquitin specific protease 17
  • ubiquitin thioesterase 17
  • ubiquitin thiolesterase 17
  • ubiquitin-specific-processing protease 17

Clone Names

  • MGC119330, MGC119331, MGC119333

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_046416.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116655
    Related
    ENST00000508843.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    9358382..9359974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    9378904..9380496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105662.1: Suppressed sequence

    Description
    NM_001105662.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials