Cdk8 Cyclin-dependent kinase 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk8provided by FlyBase
Official Full Name: Cyclin-dependent kinase 8provided by FlyBase
Primary source: FLYBASE:FBgn0015618
Locus tag: Dmel_CG10572
See related: AllianceGenome:FB:FBgn0015618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cdk8; CDK8; CG10572; dCdk8; DmCdk8; Dmel\CG10572; dTRAP56; p58
Summary: Enables kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; imaginal disc-derived leg segmentation; and sensory organ development. Located in nucleus. Part of mediator complex. Is expressed in central brain primordium; organism; and ventral nerve cord primordium. Used to study developmental and epileptic encephalopathy 87. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to several human genes including CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 67C10-67C10; 3-31 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9837080..9838670, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9830180..9831770, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During the larval-pupal transition, the levels of CDK8 protein positively correlate with EcR and USP levels.
Title: CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
observed biochemical association between Integrator proteins and cyclin C/Cdk8, and that overexpression of a kinase-dead Cdk8 causes snRNA misprocessing
Title: An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
Data demonstrate that Med12 and Med13 but not CycC or Cdk8 are essential for Serpent/Lozenge-induced transactivation in cell culture.
Title: A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in sex comb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in snRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of CKM complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of mediator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Cyclin-dependent kinase 8

Names: CG10572-PA; Cdk8-PA

NP_536735.2

EC 2.7.11.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9837080..9838670 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080487.4 → NP_536735.2 Cyclin-dependent kinase 8 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536735.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P91642, Q8MS41, Q9VT57

UniProtKB/TrEMBL

C9QP81

Related

FBpp0076098

Conserved Domains (2) summary

smart00220
Location:22 → 335

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07842
Location:19 → 335

STKc_CDK8_like; Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases